Anti-CBX2 Antibody (CAB3294)
- SKU:
- CAB3294
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CDCA6
- Synonyms:
- M33
- Synonyms:
- SRXY5
- Research Area:
- Developmental Biology
Description
| Product Name: | CBX2 Rabbit mAb |
| Product Code: | CAB3294 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CDCA6, M33, SRXY5 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CBX2 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, 293T, Mouse liver, Mouse testis, Mouse brain, Rat testis |
| Immunogen: | A synthesized peptide derived from human CBX2 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 84733 |
| Uniprot: | Q14781 |
| Calculated MW: | 56kDa |
| Observed MW: | 56kDa |
| UniProt Protein Function: | CBX2: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression. Defects in CBX2 are the cause of 46,XY sex reversal type 5 (SRXY5). It is a disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription regulation Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: nucleoplasm; nucleus; PcG protein complex Molecular Function:protein binding Biological Process: development of primary sexual characteristics; negative regulation of transcription from RNA polymerase II promoter; protein sumoylation Disease: 46,xy Sex Reversal 5 |
| NCBI Summary: | This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2010] |
| UniProt Code: | Q14781 |
| NCBI GenInfo Identifier: | 77416853 |
| NCBI Gene ID: | 84733 |
| NCBI Accession: | Q14781.2 |
| UniProt Secondary Accession: | Q14781,Q0VDA5, Q9BTB1, |
| UniProt Related Accession: | Q14781 |
| Molecular Weight: | 23,312 Da |
| NCBI Full Name: | Chromobox protein homolog 2 |
| NCBI Synonym Full Names: | chromobox 2 |
| NCBI Official Symbol: | CBX2 |
| NCBI Official Synonym Symbols: | M33; CDCA6; SRXY5 |
| NCBI Protein Information: | chromobox protein homolog 2 |
| UniProt Protein Name: | Chromobox protein homolog 2 |
| Protein Family: | Chromobox protein |
| UniProt Gene Name: | CBX2 |
| UniProt Entry Name: | CBX2_HUMAN |
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