Cell Death Antibodies 1
Anti-Caspase-5 Antibody (CAB16733)
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- SKU:
- CAB16733
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-Caspase-5 Antibody |
| Antibody SKU: | CAB16733 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 140-250 of human Caspase-5 (NP_001129584). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, HeLa, mouse liver, rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 140-250 of human Caspase-5 (NP_001129584). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QMFT QTLL NMDQ KITS VKPL LQIE AGPP ESAE STNI LKLC PREE FLRL CKKN HDEI YPIK KRED RRRL ALII CNTK FDHL PARN GAHY DIVG MKRL LQGL GYTV VDEK NLT |
| Gene ID: | 838 |
| Uniprot: | P51878 |
| Cellular Location: | |
| Calculated MW: | 49kDa |
| Observed MW: | 35kDa/50kDa |
| Synonyms: | CASP5, ICE(rel)III, ICEREL-III, ICH-3, caspase-5 |
| Background: | This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. |
| UniProt Protein Function: | CASP5: Mediator of programmed cell death (apoptosis). Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunits. Up-regulated by bacterial lipopolysaccharides (LPS). Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle. Belongs to the peptidase C14A family. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.22.58; Protease Chromosomal Location of Human Ortholog: 11q22.2-q22.3 Cellular Component: neuron projection; cell soma; cytoplasm Molecular Function:cysteine-type endopeptidase activity; cysteine-type peptidase activity Biological Process: regulation of apoptosis; substantia nigra development; apoptosis; germ cell programmed cell death; regulation of inflammatory response; positive regulation of interleukin-1 beta secretion; proteolysis |
| NCBI Summary: | This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010] |
| UniProt Code: | P51878 |
| NCBI GenInfo Identifier: | 212276423 |
| NCBI Gene ID: | 838 |
| NCBI Accession: | P51878.2 |
| UniProt Secondary Accession: | P51878,Q0QVY7, Q0QVY8, Q0QVZ0, Q0QVZ1, Q0QVZ2, Q14DD6 Q1HBJ3, Q6DJV7, B4DKP5, |
| UniProt Related Accession: | P51878 |
| Molecular Weight: | 41,851 Da |
| NCBI Full Name: | Caspase-5 |
| NCBI Synonym Full Names: | caspase 5, apoptosis-related cysteine peptidase |
| NCBI Official Symbol: | CASP5 |
| NCBI Official Synonym Symbols: | ICH-3; ICEREL-III; ICE(rel)III |
| NCBI Protein Information: | caspase-5; CASP-5; TY protease; protease TY; ICE(rel)-III; protease ICH-3; caspase 5, apoptosis-related cysteine protease |
| UniProt Protein Name: | Caspase-5 |
| UniProt Synonym Protein Names: | ICE(rel)-III; Protease ICH-3; Protease TYCleaved into the following 2 chains:Caspase-5 subunit p20; Caspase-5 subunit p10 |
| Protein Family: | Caspase |
| UniProt Gene Name: | CASP5 |
| UniProt Entry Name: | CASP5_HUMAN |
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