Anti-CASP1 Antibody (CAB20470)

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SKU:
CAB20470
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
IC
Synonyms:
ICE
Synonyms:
Il1
Synonyms:
Casp
Synonyms:
Il1bc

Description

Product Name:CASP1 Rabbit pAb
Product Code:CAB20470
Size:50uL, 100uL
Synonyms:IC, ICE, Il1, Casp, Il1bc
Applications:WB, IF
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of Mouse CASP1.
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Mouse, Rat
Positive Samples:Mouse testis
Immunogen:Recombinant protein of Mouse CASP1.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:12362
Uniprot:P29452
Calculated MW:45kDa
Observed MW:48KDa
UniProt Protein Function:CASP1: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Interacts with CARD17/INCA and CARD18. Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. Specifically inhibited by the cowpox virus Crma protein. Belongs to the peptidase C14A family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Apoptosis; EC 3.4.22.36; Protease

Cellular Component: neuron projection; protein complex; mitochondrion; cytoplasm; extracellular region; nucleus

Molecular Function:peptidase activity; protein binding; hydrolase activity; endopeptidase activity; cysteine-type peptidase activity

Biological Process: response to drug; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptosis; apoptosis; membrane hyperpolarization; microglial cell activation; interleukin-1 beta production; response to lipopolysaccharide; mitochondrial depolarization; positive regulation of interleukin-1 beta secretion; proteolysis; response to organic cyclic substance; memory; response to ATP; positive regulation of interleukin-1 alpha secretion; regulation of apoptosis; response to bacterium; regulation of inflammatory response; response to hypoxia; protein processing; regulation of autophagy; positive regulation of circadian sleep/wake cycle, non-REM sleep; myoblast fusion; positive regulation of cytokine secretion

UniProt Code:P29452
NCBI GenInfo Identifier:266322
NCBI Gene ID:12362
NCBI Accession:P29452.1
UniProt Related Accession:P29452
Molecular Weight:
NCBI Full Name:Caspase-1
NCBI Synonym Full Names:caspase 1
NCBI Official Symbol:Casp1  
NCBI Official Synonym Symbols:ICE; Il1bc  
NCBI Protein Information:caspase-1; p45; CASP-1; IL-1BC; IL-1B converting enzyme; IL-1 beta-converting enzyme; interleukin-1 beta convertase; interleukin 1 beta-converting enzyme; interleukin-1 beta-converting enzyme
UniProt Protein Name:Caspase-1
UniProt Synonym Protein Names:Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45Cleaved into the following 2 chains:Caspase-1 subunit p20; Caspase-1 subunit p10
UniProt Gene Name:Casp1  
UniProt Entry Name:CASP1_MOUSE
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