Metabolism Antibodies 3
Anti-Casein Kinase 2 beta Antibody (CAB4519)
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- SKU:
- CAB4519
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-Casein Kinase 2 beta Antibody |
| Antibody SKU: | CAB4519 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Casein Kinase 2 beta |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, K-562, U-251MG, Mouse testis, Mouse spleen, Mouse kidney, Rat testis |
| Immunogen: | A synthesized peptide derived from human Casein Kinase 2 beta |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1460 |
| Uniprot: | P67870 |
| Cellular Location: | |
| Calculated MW: | 25kDa |
| Observed MW: | 25KDa |
| Synonyms: | CK2B, CK2N, CSK2B, G5A |
| Background: | This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] |
| UniProt Protein Function: | CK2B: a regulatory subunit of the casein kinase 2 holoenzyme. Exists as a tetramer composed of two catalytic subunits, alpha and alpha-prime, and two regulatory beta subunits. The beta subunits undergo autophosphorylation. Plays a complex role in regulating the basal catalytic activity of the alpha subunit. Participates in Wnt signaling |
| UniProt Protein Details: | Protein type:Protein kinase, regulatory subunit Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; PcG protein complex; plasma membrane Molecular Function:chromatin binding; identical protein binding; protein binding; protein domain specific binding; protein serine/threonine kinase activity; receptor binding; transcription factor binding Biological Process: adiponectin-mediated signaling pathway; negative regulation of blood vessel endothelial cell migration; negative regulation of cell proliferation; positive regulation of activin receptor signaling pathway; protein folding; signal transduction |
| NCBI Summary: | This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] |
| UniProt Code: | P67870 |
| NCBI GenInfo Identifier: | 54037520 |
| NCBI Gene ID: | 1460 |
| NCBI Accession: | P67870.1 |
| UniProt Secondary Accession: | P67870,P07312, P13862, Q4VX47, B0UXA9, |
| UniProt Related Accession: | P67870 |
| Molecular Weight: | 24,942 Da |
| NCBI Full Name: | Casein kinase II subunit beta |
| NCBI Synonym Full Names: | casein kinase 2 beta |
| NCBI Official Symbol: | CSNK2B |
| NCBI Official Synonym Symbols: | G5A; CK2B; CK2N; CSK2B |
| NCBI Protein Information: | casein kinase II subunit beta |
| UniProt Protein Name: | Casein kinase II subunit beta |
| UniProt Synonym Protein Names: | Phosvitin; Protein G5a |
| UniProt Gene Name: | CSNK2B |
| UniProt Entry Name: | CSK2B_HUMAN |
 | Western blot - Casein Kinase 2 beta Rabbit mAb (CAB4519) |
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