Developmental Biology

Anti-CAPRIN2 Antibody (CAB17365)

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SKU:
CAB17365
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-CAPRIN2 Antibody
Antibody SKU:CAB17365
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human CAPRIN2.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:SH-SY5Y, 293T, C6
Immunogen:Recombinant protein of human CAPRIN2.
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:65981
Uniprot:Q6IMN6
Cellular Location:
Calculated MW:126kDa
Observed MW:126kDa
Synonyms:EEG1, EEG-1, C1QDC1, RNG140, CAPRIN2
Background:The protein encoded by this gene may regulate the transport of mRNA. It may play a role in the differentiation of erythroblasts. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:C1QDC1: May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis. Belongs to the caprin family. 9 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 12p11

Cellular Component: nucleoplasm; centrosome; mitochondrion; cytoplasm; nucleus; receptor complex

Molecular Function:protein binding; RNA binding; receptor binding

Biological Process: positive regulation of protein binding; negative regulation of translation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell growth; positive regulation of dendrite morphogenesis; positive regulation of peptidyl-serine phosphorylation

NCBI Summary:The protein encoded by this gene may be involved in the transitioning of erythroblasts from a highly proliferative state to a terminal phase of differentiation. High level expression of the encoded protein can lead to apoptosis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
UniProt Code:Q6IMN6
NCBI GenInfo Identifier:74748798
NCBI Gene ID:65981
NCBI Accession:Q6IMN6.1
UniProt Secondary Accession:Q6IMN6,Q149P6, Q149P7, Q6IMN5, Q7Z371, Q8TE70, Q8TE71 Q96RN6, Q9H667, Q9HAL4, E4NKG2,
UniProt Related Accession:Q6IMN6
Molecular Weight:101,929 Da
NCBI Full Name:Caprin-2
NCBI Synonym Full Names:caprin family member 2
NCBI Official Symbol:CAPRIN2  
NCBI Official Synonym Symbols:EEG1; EEG-1; C1QDC1; RNG140  
NCBI Protein Information:caprin-2; RNA granule protein 140; C1q domain-containing protein 1; gastric cancer multidrug resistance-associated protein; cytoplasmic activation/proliferation-associated protein 2
UniProt Protein Name:Caprin-2
UniProt Synonym Protein Names:C1q domain-containing protein 1; Cytoplasmic activation/proliferation-associated protein 2; Gastric cancer multidrug resistance-associated protein; Protein EEG-1; RNA granule protein 140
Protein Family:Caprin
UniProt Gene Name:CAPRIN2  
UniProt Entry Name:CAPR2_HUMAN
Anti-CAPRIN2 Antibody (CAB17365)Western blot analysis of extracts of various cell lines, using CAPRIN2 antibody (CAB17365) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 3min.
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