Signal Transduction Antibodies 3
Anti-CAPN9 Antibody (CAB17085)
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- SKU:
- CAB17085
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-CAPN9 Antibody |
| Antibody SKU: | CAB17085 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 391-690 of human CAPN9 (NP_006606.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 391-690 of human CAPN9 (NP_006606.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QEEC SFLV ALMQ KDRR KLKR FGAN VLTI GYAI YECP DKDE HLNK DFFR YHAS RARS KTFI NLRE VSDR FKLP PGEY ILIP STFE PHQE ADFC LRIF SEKK AITR DMDG NVDI DLPE PPKP TPPD QETE EEQR FRAL FEQV AGED MEVT AEEL EYVL NAVL QKKK DIKF KKLS LISC KNII SLMD TSGN GKLE FDEF KVFW DKLK QWIN LFLR FDAD KSGT MSTY ELRT ALKA AGFQ LSSH LLQL IVLR YADE ELQL DFDD FLNC LVRL ENAS RVFQ ALST KNKE FIHL NINE FIHL TMNI |
| Gene ID: | 10753 |
| Uniprot: | O14815 |
| Cellular Location: | |
| Calculated MW: | 76kDa/79kDa |
| Observed MW: | Refer to figures |
 | Immunohistochemistry - CAPN9 Polyclonal Antibody (CAB17085) |
| Synonyms: | CAPN9, GC36, nCL-4, calpain-9 |
| Background: | Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CAPN9: Calcium-regulated non-lysosomal thiol-protease. Belongs to the peptidase C2 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Calcium-binding; EC 3.4.22.-; Protease Chromosomal Location of Human Ortholog: 1q42.11-q42.3 Cellular Component: cytoplasm |
| NCBI Summary: | Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14815 |
| NCBI GenInfo Identifier: | 32129432 |
| NCBI Gene ID: | 10753 |
| NCBI Accession: | O14815.1 |
| UniProt Secondary Accession: | O14815,Q9NS74, B1APS1, B1AQI0, |
| UniProt Related Accession: | O14815 |
| Molecular Weight: | 76,168 Da |
| NCBI Full Name: | Calpain-9 |
| NCBI Synonym Full Names: | calpain 9 |
| NCBI Official Symbol: | CAPN9 |
| NCBI Official Synonym Symbols: | GC36; nCL-4 |
| NCBI Protein Information: | calpain-9 |
| UniProt Protein Name: | Calpain-9 |
| UniProt Synonym Protein Names: | Digestive tract-specific calpain; New calpain 4; nCL-4; Protein CG36 |
| Protein Family: | Calpain |
| UniProt Gene Name: | CAPN9 |
| UniProt Entry Name: | CAN9_HUMAN |
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