Epigenetics & Nuclear Signaling Antibodies 2

Anti-CAND2 Antibody (CAB16500)

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SKU:
CAB16500
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-CAND2 Antibody
Antibody SKU:CAB16500
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 850-1000 of human CAND2 (NP_001155971.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, 293T, Jurkat, NIH/3T3, Mouse heart, Rat heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 850-1000 of human CAND2 (NP_001155971.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VGQV AGPG HQRE LKAV LLEA LGSP SEDV RAAA SYAL GRVG AGSL PDFL PFLL EQIE AEPR RQYL LLHS LREA LGAA QPDS LKPY AEDI WALL FQRC EGAE EGTR GVVA ECIG KLVL VNPS FLLP RLRK QLAA GRPH TRST VITA VKFL ISD
Gene ID:23066
Uniprot:O75155
Cellular Location:Nucleus
Calculated MW:122kDa/135kDa
Observed MW:130kDa
Synonyms:CAND2, TIP120B, Tp120b
Background:
UniProt Protein Function:CAND2: May play a role in the assembly of ubiquitin ligase complexes and modulate the ubiquitination of target proteins. May be a transcription regulator (Potential). Belongs to the CAND family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 3p25.2

Cellular Component: intracellular; nucleus

Molecular Function:protein binding; TATA-binding protein binding

Biological Process: transcription, DNA-dependent; SCF complex assembly; positive regulation of transcription, DNA-dependent; protein ubiquitination

UniProt Code:O75155
NCBI GenInfo Identifier:112420977
NCBI Gene ID:23066
NCBI Accession:NP_036430
UniProt Related Accession:O75155
Molecular Weight:123kDa
NCBI Full Name:cullin-associated NEDD8-dissociated protein 2 isoform 2
NCBI Synonym Full Names:cullin associated and neddylation dissociated 2 (putative)
NCBI Official Symbol:CAND2  
NCBI Official Synonym Symbols:Tp120b; TIP120B  
NCBI Protein Information:cullin-associated NEDD8-dissociated protein 2
UniProt Protein Name:Cullin-associated NEDD8-dissociated protein 2
UniProt Synonym Protein Names:Cullin-associated and neddylation-dissociated protein 2; Epididymis tissue protein Li 169; TBP-interacting protein of 120 kDa B; TBP-interacting protein 120B; p120 CAND2
Protein Family:Cullin-associated NEDD8-dissociated protein
UniProt Gene Name:CAND2  
UniProt Entry Name:CAND2_HUMAN
Anti-CAND2 Antibody (CAB16500)Western blot analysis of extracts of various cell lines, using CAND2 antibody (CAB16500) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
Anti-CAND2 Antibody (CAB16500)Immunohistochemistry of paraffin-embedded Mouse spleen using CAND2 Rabbit pAb (CAB16500) at dilution of 1:100 (40x lens).
Anti-CAND2 Antibody (CAB16500)Immunohistochemistry of paraffin-embedded Rat testis using CAND2 Rabbit pAb (CAB16500) at dilution of 1:100 (40x lens).
Anti-CAND2 Antibody (CAB16500)Immunohistochemistry of paraffin-embedded Human colon carcinoma using CAND2 Rabbit pAb (CAB16500) at dilution of 1:100 (40x lens).
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