Cell Biology Antibodies 12
Anti-CAMSAP2 Antibody (CAB9315)
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- SKU:
- CAB9315
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CAMSAP2 Antibody |
| Antibody SKU: | CAB9315 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human CAMSAP2 (NP_982284.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-87MG, MCF7, NCI-H460 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human CAMSAP2 (NP_982284.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGDA ADPR EMRK TFIV PAIK PFDH YDFS RAKI ACNL AWLV AKAF GTEN VPEE LQEP FYTD QYDQ EHIK PPVV NLLL SAEL YCRA GSLI LKSD AAKP LLGH DAVI QALA QKGL YVTD QEKL VTER DLHK KPIQ MSAH LAMI DTLM MAYT VE |
| Gene ID: | 23271 |
| Uniprot: | Q08AD1 |
| Cellular Location: | Cytoplasm, cytoskeleton |
| Calculated MW: | 165kDa/166kDa/168kDa |
| Observed MW: | 189kDa |
| Synonyms: | CAMSAP2, CAMSAP1L1 |
| Background: |
| UniProt Protein Function: | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). |
| UniProt Code: | Q08AD1 |
| NCBI GenInfo Identifier: | 663071131 |
| NCBI Gene ID: | 23271 |
| NCBI Accession: | NP_001284636.1 |
| UniProt Secondary Accession: | Q08AD1,Q08AD2, Q6PGN8, Q96FB3, Q9UG20, Q9UPS4, B1APG6 |
| UniProt Related Accession: | Q08AD1 |
| Molecular Weight: | Calculated: 1478aa, 167kDaObserved: 170-200kDa |
| NCBI Full Name: | calmodulin-regulated spectrin-associated protein 2 isoform 1 |
| NCBI Synonym Full Names: | calmodulin regulated spectrin associated protein family member 2 |
| NCBI Official Symbol: | CAMSAP2 |
| NCBI Official Synonym Symbols: | CAMSAP1L1 |
| NCBI Protein Information: | calmodulin-regulated spectrin-associated protein 2 |
| UniProt Protein Name: | Calmodulin-regulated spectrin-associated protein 2 |
| UniProt Synonym Protein Names: | Calmodulin-regulated spectrin-associated protein 1-like protein 1 |
| Protein Family: | Calmodulin-regulated spectrin-associated protein |
| UniProt Gene Name: | CAMSAP2 |
 | Western blot analysis of extracts of various cell lines, using CAMSAP2 Antibody (CAB9315) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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