Cell Biology Antibodies 12
Anti-Calretinin Antibody (CAB9807)
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- SKU:
- CAB9807
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Calretinin Antibody |
| Antibody SKU: | CAB9807 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-271 of human CALB2 (NP_001731.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:1000 - 1:4000 IHC 1:50 - 1:100 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW480, Mouse eye, Mouse brain, Rat spinal cord, Rat brain, Mouse small intestine, Mouse spinal cord, Rat eye |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-271 of human CALB2 (NP_001731.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAGP QQQP PYLH LAEL TASQ FLEI WKHF DADG NGYI EGKE LENF FQEL EKAR KGSG MMSK SDNF GEKM KEFM QKYD KNSD GKIE MAEL AQIL PTEE NFLL CFRQ HVGS SAEF MEAW RKYD TDRS GYIE ANEL KGFL SDLL KKAN RPYD EPKL QEYT QTIL RMFD LNGD GKLG LSEM SRLL PVQE NFLL KFQG MKLT SEEF NAIF TFYD KDRS GYID EHEL DALL KDLY EKNK KEMN IQQL TNYR KSVM SLAE AGKL YRKD LEIV LCSE PPM |
| Gene ID: | 794 |
| Uniprot: | P22676 |
| Cellular Location: | |
| Calculated MW: | 31kDa |
| Observed MW: | 29kDa |
| Synonyms: | CALB2, CAB29, CAL2, CR |
| Background: | This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CALB2: Calretinin is a calcium-binding protein which is abundant in auditory neurons. Belongs to the calbindin family. |
| UniProt Protein Details: | Protein type:Calcium-binding Chromosomal Location of Human Ortholog: 16q22.2 Cellular Component: cytoplasm; gap junction; nucleus Molecular Function:calcium ion binding Biological Process: cytosolic calcium ion homeostasis |
| NCBI Summary: | This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] |
| UniProt Code: | P22676 |
| NCBI GenInfo Identifier: | 109940061 |
| NCBI Gene ID: | 794 |
| NCBI Accession: | P22676.2 |
| UniProt Secondary Accession: | P22676,Q53HD2, Q96BK4, A8K4Y1, |
| UniProt Related Accession: | P22676 |
| Molecular Weight: | 31,540 Da |
| NCBI Full Name: | Calretinin |
| NCBI Synonym Full Names: | calbindin 2 |
| NCBI Official Symbol: | CALB2 |
| NCBI Official Synonym Symbols: | CR; CAL2; CAB29 |
| NCBI Protein Information: | calretinin; calbindin D29K; 29 kDa calbindin; calbindin 2, (29kD, calretinin) |
| UniProt Protein Name: | Calretinin |
| UniProt Synonym Protein Names: | 29 kDa calbindin |
| UniProt Gene Name: | CALB2 |
| UniProt Entry Name: | CALB2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CALB2 antibody (CAB9807) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunohistochemistry of paraffin-embedded mouse kidney using CALB2 antibody (CAB9807) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using CALB2 antibody (CAB9807) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of rat brain using CALB2 antibody (CAB9807) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of mouse brain using CALB2 antibody (CAB9807) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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