Cell Death Antibodies 1

Anti-CADM1 Antibody (CAB1892)

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SKU:
CAB1892
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death

Description

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Antibody Name:Anti-CADM1 Antibody
Antibody SKU:CAB1892
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 45-344 of human CADM1 (NP_001091987.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:SW480, Mouse brain, Mouse testis, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 45-344 of human CADM1 (NP_001091987.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QNLF TKDV TVIE GEVA TISC QVNK SDDS VIQL LNPN RQTI YFRD FRPL KDSR FQLL NFSS SELK VSLT NVSI SDEG RYFC QLYT DPPQ ESYT TITV LVPP RNLM IDIQ KDTA VEGE EIEV NCTA MASK PATT IRWF KGNT ELKG KSEV EEWS DMYT VTSQ LMLK VHKE DDGV PVIC QVEH PAVT GNLQ TQRY LEVQ YKPQ VHIQ MTYP LQGL TREG DALE LTCE AIGK PQPV MVTW VRVD DEMP QHAV LSGP NLFI NNLN KTDN GTYR CEAS NIVG KAHS DYML YVYD SRAG EEGS IRAV
Gene ID:23705
Uniprot:Q9BY67
Cellular Location:Cell junction, Cell membrane, Single-pass type I membrane protein, synapse
Calculated MW:36kDa/45kDa/48kDa/49kDa/51kDa
Observed MW:67kDa
Synonyms:CADM1, BL2, IGSF4, IGSF4A, NECL2, Necl-2, RA175, ST17, SYNCAM, TSLC1, sTSLC-1, sgIGSF, synCAM1
Background:
UniProt Protein Function:CADM1: a single-pass type I membrane protein that ediates homophilic cell-cell adhesion, and heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. Belongs to the nectin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Apoptosis; Cell adhesion; Membrane protein, integral; Tumor suppressor; Vesicle

Chromosomal Location of Human Ortholog: 11q23.2

Cellular Component: basolateral plasma membrane; cell-cell adherens junction; integral to plasma membrane; intercellular junction; plasma membrane

Molecular Function:cell adhesion molecule binding; PDZ domain binding; protein binding; protein homodimerization activity; receptor activity; receptor binding

Biological Process: activated T cell proliferation; cell recognition; detection of stimulus; heterophilic cell adhesion; homophilic cell adhesion; positive regulation of cytokine secretion; positive regulation of natural killer cell mediated cytotoxicity; susceptibility to natural killer cell mediated cytotoxicity; T cell mediated cytotoxicity

UniProt Code:Q9BY67
NCBI GenInfo Identifier:150438862
NCBI Gene ID:23705
NCBI Accession:Q9BY67.2
UniProt Secondary Accession:Q9BY67,Q86WB8, Q8N2F4, A4FVB5, F5H0J4, H0YGA7, H1ZZV9 H1ZZW1, H1ZZW2, X5D2C8,
UniProt Related Accession:Q9BY67
Molecular Weight:45,624 Da
NCBI Full Name:Cell adhesion molecule 1
NCBI Synonym Full Names:cell adhesion molecule 1
NCBI Official Symbol:CADM1  
NCBI Official Synonym Symbols:BL2; ST17; IGSF4; NECL2; RA175; TSLC1; IGSF4A; Necl-2; SYNCAM; sgIGSF; sTSLC-1; synCAM1  
NCBI Protein Information:cell adhesion molecule 1
UniProt Protein Name:Cell adhesion molecule 1
UniProt Synonym Protein Names:Immunoglobulin superfamily member 4; IgSF4; Nectin-like protein 2; NECL-2; Spermatogenic immunoglobulin superfamily; SgIgSF; Synaptic cell adhesion molecule; SynCAM; Tumor suppressor in lung cancer 1; TSLC-1
Protein Family:Cell adhesion molecule
UniProt Gene Name:CADM1  
UniProt Entry Name:CADM1_HUMAN
Anti-CADM1 Antibody (CAB1892)Western blot analysis of extracts of various cell lines, using CADM1 antibody (CAB1892) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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