Cell Biology Antibodies 5
Anti-CACNB3 Antibody (CAB14710)
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- SKU:
- CAB14710
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CACNB3 Antibody |
| Antibody SKU: | CAB14710 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 355-484 of human CACNB3 (NP_000716.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 355-484 of human CACNB3 (NP_000716.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VYWR ATHH PAPG PGLL GPPS AIPG LQNQ QLLG ERGE EHSP LERD SLMP SDEA SESS RQAW TGSS QRSS RHLE EDYA DAYQ DLYQ PHRQ HTSG LPSA NGHD PQDR LLAQ DSEH NHSD RNWQ RNRP WPKD SY |
| Gene ID: | 784 |
| Uniprot: | P54284 |
| Cellular Location: | |
| Calculated MW: | 50kDa/53kDa/54kDa |
| Observed MW: | 58kDa |
| Synonyms: | CACNB3, CAB3, CACNLB3 |
| Background: | This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. |
| UniProt Protein Function: | CACNB3: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Belongs to the calcium channel beta subunit family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Channel, calcium Chromosomal Location of Human Ortholog: 12q13 Cellular Component: cytosol; membrane; plasma membrane; voltage-gated calcium channel complex Molecular Function:calcium channel activity; high voltage-gated calcium channel activity; voltage-gated calcium channel activity Biological Process: calcium ion transport; membrane depolarization; neuromuscular junction development; synaptic transmission; transport |
| NCBI Summary: | This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011] |
| UniProt Code: | P54284 |
| NCBI GenInfo Identifier: | 1705683 |
| NCBI Gene ID: | 784 |
| NCBI Accession: | P54284.1 |
| UniProt Secondary Accession: | P54284,Q13913, A8K0Z4, B7Z4Q1, B7Z973, B7ZAK8, F5GZW7 F5H2P6, F8VSG3, |
| UniProt Related Accession: | P54284 |
| Molecular Weight: | 50,015 Da |
| NCBI Full Name: | Voltage-dependent L-type calcium channel subunit beta-3 |
| NCBI Synonym Full Names: | calcium voltage-gated channel auxiliary subunit beta 3 |
| NCBI Official Symbol: | CACNB3 |
| NCBI Official Synonym Symbols: | CAB3; CACNLB3 |
| NCBI Protein Information: | voltage-dependent L-type calcium channel subunit beta-3 |
| UniProt Protein Name: | Voltage-dependent L-type calcium channel subunit beta-3 |
| UniProt Synonym Protein Names: | Calcium channel voltage-dependent subunit beta 3 |
| Protein Family: | Voltage-dependent L-type calcium channel |
| UniProt Gene Name: | CACNB3 |
| UniProt Entry Name: | CACB3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CACNB3 antibody (CAB14710) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat ovary using CACNB3 antibody (CAB14710) at dilution of 1:150 (40x lens). |
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