Cell Biology Antibodies 1
Anti-CACNA1E Antibody (CAB10203)
(No reviews yet)
Write a Review
- SKU:
- CAB10203
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CACNA1E Antibody |
| Antibody SKU: | CAB10203 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 2014-2313 of human CACNA1E (NP_001192222.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, 293T, Mouse brain, Mouse liver, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 2014-2313 of human CACNA1E (NP_001192222.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PSSM RRSF STIR DKRS NSSW LEEF SMER SSEN TYKS RRRS YHSS LRLS AHRL NSDS GHKS DTHR SGGR ERGR SKER KHLL SPDV SRCN SEER GTQA DWES PERR QSRS PSEG RSQT PNRQ GTGS LSES SIPS VSDT STPR RSRR QLPP VPPK PRPL LSYS SLIR HAGS ISPP ADGS EEGS PLTS QALE SNNA CLTE SSNS PHPQ QSQH ASPQ RYIS EPYL ALHE DSHA SDCG EEET LTFE AAVA TSLG RSNT IGSA PPLR HSWQ MPNG HYRR RRRG GPGP GMMC GAVN NLLS DTEE DDKC |
| Gene ID: | 777 |
| Uniprot: | Q15878 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 254kDa/257kDa/261kDa |
| Observed MW: | 290kDa |
| Synonyms: | CACNA1E, BII, CACH6, CACNL1A6, Cav2.3, gm139 |
| Background: | Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | CACNA1E: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega- conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega- Aga-IVA). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1E subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 1q25.3 Cellular Component: plasma membrane Molecular Function:calcium channel activity; high voltage-gated calcium channel activity; voltage-gated calcium channel activity Biological Process: membrane depolarization; regulation of insulin secretion; synaptic transmission; transport |
| NCBI Summary: | Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011] |
| UniProt Code: | Q15878 |
| NCBI GenInfo Identifier: | 209572758 |
| NCBI Gene ID: | 777 |
| NCBI Accession: | Q15878.3 |
| UniProt Secondary Accession: | Q15878,Q14580, Q14581, B1AM12, B1AM13, B1AM14, |
| UniProt Related Accession: | Q15878 |
| Molecular Weight: | 262kDa |
| NCBI Full Name: | Voltage-dependent R-type calcium channel subunit alpha-1E |
| NCBI Synonym Full Names: | calcium voltage-gated channel subunit alpha1 E |
| NCBI Official Symbol: | CACNA1E |
| NCBI Official Synonym Symbols: | BII; CACH6; gm139; Cav2.3; CACNL1A6 |
| NCBI Protein Information: | voltage-dependent R-type calcium channel subunit alpha-1E |
| UniProt Protein Name: | Voltage-dependent R-type calcium channel subunit alpha-1E |
| UniProt Synonym Protein Names: | Brain calcium channel II; BII; Calcium channel, L type, alpha-1 polypeptide, isoform 6; Voltage-gated calcium channel subunit alpha Cav2.3 |
| Protein Family: | Voltage-dependent R-type calcium channel |
| UniProt Gene Name: | CACNA1E |
 | Western blot analysis of extracts of various cell lines, using CACNA1E antibody (CAB10203) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
View AllClose
Related Products
CACNA1S Polyclonal Antibody
OverviewProduct Name:CACNA1S Polyclonal AntibodyProduct Code:CAB23062Reactivity:Mouse, RatApplications:Immunofluorescence
CACNA1C Polyclonal Antibody
CACNA1C Polyclonal AntibodyThe product page for this antibody is being prepared. If you have a question please don't hesitate to get in touch!
