Immunology Antibodies 2
Anti-C9 Antibody (CAB5622)
- SKU:
- CAB5622
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-C9 Antibody |
| Antibody SKU: | CAB5622 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-265 of human C9 (NP_001728.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-265 of human C9 (NP_001728.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QYTT SYDP ELTE SSGS ASHI DCRM SPWS EWSQ CDPC LRQM FRSR SIEV FGQF NGKR CTDA VGDR RQCV PTEP CEDA EDDC GNDF QCST GRCI KMRL RCNG DNDC GDFS DEDD CESE PRPP CRDR VVEE SELA RTAG YGIN ILGM DPLS TPFD NEFY NGLC NRDR DGNT LTYY RRPW NVAS LIYE TKGE KNFR TEHY EEQI EAFK SIIQ EKTS NFNA AISL KFTP TETN KAEQ CCEE TASS ISLH |
| Gene ID: | 735 |
| Uniprot: | P02748 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein, Secreted |
| Calculated MW: | 63kDa |
| Observed MW: | 70kDa |
| Synonyms: | C9, ARMD15, C9D |
| Background: | This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. |
| UniProt Protein Function: | C9: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC. Defects in C9 are a cause of complement component 9 deficiency (C9D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family. |
| UniProt Protein Details: | Protein type:Extracellular matrix; Membrane protein, multi-pass; Membrane protein, integral; Apoptosis Chromosomal Location of Human Ortholog: 5p14-p12 Cellular Component: membrane attack complex; integral to plasma membrane; cytoplasm; plasma membrane; extracellular region Biological Process: complement activation, alternative pathway; regulation of complement activation; innate immune response; hemolysis by symbiont of host red blood cells; complement activation, classical pathway Disease: Macular Degeneration, Age-related, 15; Complement Component 9 Deficiency |
| NCBI Summary: | This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. [provided by RefSeq, Feb 2009] |
| UniProt Code: | P02748 |
| NCBI GenInfo Identifier: | 1352108 |
| NCBI Gene ID: | 735 |
| NCBI Accession: | P02748.2 |
| UniProt Related Accession: | P02748 |
| Molecular Weight: | |
| NCBI Full Name: | Complement component C9 |
| NCBI Synonym Full Names: | complement component 9 |
| NCBI Official Symbol: | C9 |
| NCBI Official Synonym Symbols: | C9D; ARMD15 |
| NCBI Protein Information: | complement component C9 |
| UniProt Protein Name: | Complement component C9 |
| Protein Family: | Complement component |
| UniProt Gene Name: | C9 |
| UniProt Entry Name: | CO9_HUMAN |
 | Western blot analysis of extracts of mouse liver, using C9 antibody (CAB5622) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
View AllClose
Related Products
Human Complement C9 / C9 ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
