Immunology Antibodies 2
Anti-C7 Antibody (CAB5394)
- SKU:
- CAB5394
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-C7 Antibody |
| Antibody SKU: | CAB5394 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-270 of human C7 (NP_000578.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, |
| Positive Samples: | Lovo, BT-474, SGC996 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-270 of human C7 (NP_000578.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ASSP VNCQ WDFY APWS ECNG CTKT QTRR RSVA VYGQ YGGQ PCVG NAFE TQSC EPTR GCPT EEGC GERF RCFS GQCI SKSL VCNG DSDC DEDS ADED RCED SERR PSCD IDKP PPNI ELTG NGYN ELTG QFRN RVIN TKSF GGQC RKVF SGDG KDFY RLSG NVLS YTFQ VKIN NDFN YEFY NSTW SYVK HTST EHTS SSRK RSFF RSSS SSSR SYTS HTNE IHKG KSYQ LLVV ENTV EVAQ FINN NPEF L |
| Gene ID: | 730 |
| Uniprot: | P10643 |
| Cellular Location: | Secreted |
| Calculated MW: | 93kDa |
| Observed MW: | 112kDa |
| Synonyms: | C7 |
| Background: | C7 is a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. |
| UniProt Protein Function: | C7: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor. Defects in C7 are a cause of complement component 7 deficiency (C7D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 5p13 Cellular Component: extracellular region; membrane attack complex Biological Process: complement activation; complement activation, alternative pathway; complement activation, classical pathway; cytolysis; innate immune response; regulation of complement activation Disease: Complement Component 7 Deficiency |
| NCBI Summary: | C7 is a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P10643 |
| NCBI GenInfo Identifier: | 61252057 |
| NCBI Gene ID: | 730 |
| NCBI Accession: | P10643.2 |
| UniProt Secondary Accession: | P10643,Q6P3T5, Q92489, |
| UniProt Related Accession: | P10643 |
| Molecular Weight: | 93,518 Da |
| NCBI Full Name: | Complement component C7 |
| NCBI Synonym Full Names: | complement component 7 |
| NCBI Official Symbol: | C7 |
| NCBI Protein Information: | complement component C7 |
| UniProt Protein Name: | Complement component C7 |
| Protein Family: | Complement component |
| UniProt Gene Name: | C7 |
| UniProt Entry Name: | CO7_HUMAN |
 | Western blot analysis of extracts of various cell lines, using C7 antibody (CAB5394) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
 | Immunofluorescence analysis of HeLa cells using C7 Rabbit pAb (CAB5394) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of NIH/3T3 cells using C7 Rabbit pAb (CAB5394) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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