Immunology Antibodies 1
Anti-C1S Antibody (CAB13675)
- SKU:
- CAB13675
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-C1S Antibody |
| Antibody SKU: | CAB13675 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 479-688 of human C1S (NP_958850.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HepG2, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 479-688 of human C1S (NP_958850.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GNRE PTMY VGST SVQT SRLA KSKM LTPE HVFI HPGW KLLE VPEG RTNF DNDI ALVR LKDP VKMG PTVS PICL PGTS SDYN LMDG DLGL ISGW GRTE KRDR AVRL KAAR LPVA PLRK CKEV KVEK PTAD AEAY VFTP NMIC AGGE KGMD SCKG DSGG AFAV QDPN DKTK FYAA GLVS WGPQ CGTY GLYT RVKN YVDW IMKT MQEN STPR ED |
| Gene ID: | 716 |
| Uniprot: | P09871 |
| Cellular Location: | |
| Calculated MW: | 76kDa |
| Observed MW: | 100kDa |
| Synonyms: | C1S, EDSPD2 |
| Background: | This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. |
| UniProt Protein Function: | C1S: C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. Defects in C1S are the cause of complement component C1s deficiency (C1SD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. Belongs to the peptidase S1 family. |
| UniProt Protein Details: | Protein type:EC 3.4.21.42; Protease Chromosomal Location of Human Ortholog: 12p13 Cellular Component: extracellular region Molecular Function:identical protein binding; protein binding; serine-type endopeptidase activity; calcium ion binding Biological Process: innate immune response; proteolysis; complement activation, classical pathway; complement activation Disease: Complement Component C1s Deficiency |
| NCBI Summary: | This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009] |
| UniProt Code: | P09871 |
| NCBI GenInfo Identifier: | 115205 |
| NCBI Gene ID: | 716 |
| NCBI Accession: | P09871.1 |
| UniProt Secondary Accession: | P09871,Q9UCU7, Q9UCU8, Q9UCU9, Q9UCV0, Q9UCV1, Q9UCV2 Q9UCV3, Q9UCV4, Q9UCV5, Q9UM14, D3DUT4, |
| UniProt Related Accession: | P09871 |
| Molecular Weight: | 76,684 Da |
| NCBI Full Name: | Complement C1s subcomponent |
| NCBI Synonym Full Names: | complement component 1, s subcomponent |
| NCBI Official Symbol: | C1S |
| NCBI Protein Information: | complement C1s subcomponent; C1 esterase; basic proline-rich peptide IB-1; complement component 1 subcomponent s |
| UniProt Protein Name: | Complement C1s subcomponent |
| UniProt Synonym Protein Names: | C1 esterase; Complement component 1 subcomponent sCleaved into the following 2 chains:Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain |
| UniProt Gene Name: | C1S |
| UniProt Entry Name: | C1S_HUMAN |
 | Western blot analysis of extracts of various cell lines, using C1S antibody (CAB13675) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of HeLa cells using C1S antibody (CAB13675). |
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