Immunology Antibodies 2
Anti-C1R Antibody (CAB6360)
- SKU:
- CAB6360
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-C1R Antibody |
| Antibody SKU: | CAB6360 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 466-705 of human C1R (NP_001724.3). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse bone marrow |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 466-705 of human C1R (NP_001724.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GGQK AKMG NFPW QVFT NIHG RGGG ALLG DRWI LTAA HTLY PKEH EAQS NASL DVFL GHTN VEEL MKLG NHPI RRVS VHPD YRQD ESYN FEGD IALL ELEN SVTL GPNL LPIC LPDN DTFY DLGL MGYV SGFG VMEE KIAH DLRF VRLP VANP QACE NWLR GKNR MDVF SQNM FCAG HPSL KQDA CQGD SGGV FAVR DPNT DRWV ATGI VSWG IGCS RGYG FYTK VLNY VDWI KKEM EEED |
| Gene ID: | 715 |
| Uniprot: | P00736 |
| Cellular Location: | |
| Calculated MW: | 80kDa |
| Observed MW: | 80kDa |
| Synonyms: | C1R, EDSPD1 |
| Background: |
| UniProt Protein Function: | C1R: C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. Belongs to the peptidase S1 family. |
| UniProt Protein Details: | Protein type:EC 3.4.21.41; Protease Chromosomal Location of Human Ortholog: 12p13 Cellular Component: extracellular region Molecular Function:protein binding; serine-type peptidase activity; serine-type endopeptidase activity; calcium ion binding Biological Process: innate immune response; immune response; proteolysis; complement activation, classical pathway; complement activation Disease: Complement Component C1r/c1s Deficiency |
| UniProt Code: | P00736 |
| NCBI GenInfo Identifier: | 218511956 |
| NCBI Gene ID: | 715 |
| NCBI Accession: | P00736.2 |
| UniProt Secondary Accession: | P00736,Q68D77, Q8J012, A6NJQ8, |
| UniProt Related Accession: | P00736 |
| Molecular Weight: | 705 |
| NCBI Full Name: | Complement C1r subcomponent |
| NCBI Synonym Full Names: | complement component 1, r subcomponent |
| NCBI Official Symbol: | C1R |
| NCBI Protein Information: | complement C1r subcomponent |
| UniProt Protein Name: | Complement C1r subcomponent |
| UniProt Synonym Protein Names: | Complement component 1 subcomponent rCleaved into the following 2 chains:Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain |
| Protein Family: | Complement C1r subcomponent |
| UniProt Gene Name: | C1R |
| UniProt Entry Name: | C1R_HUMAN |
 | Western blot analysis of extracts of mouse bone marrow, using C1R antibody (CAB6360) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunofluorescence analysis of HeLa cells using C1R antibody (CAB6360). Blue: DAPI for nuclear staining. |
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