Immunology Antibodies 2

Anti-C1R Antibody (CAB15650)

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SKU:
CAB15650
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-C1R Antibody
Antibody SKU:CAB15650
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 466-705 of human C1R (NP_001724.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, Mouse liver, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 466-705 of human C1R (NP_001724.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GGQK AKMG NFPW QVFT NIHG RGGG ALLG DRWI LTAA HTLY PKEH EAQS NASL DVFL GHTN VEEL MKLG NHPI RRVS VHPD YRQD ESYN FEGD IALL ELEN SVTL GPNL LPIC LPDN DTFY DLGL MGYV SGFG VMEE KIAH DLRF VRLP VANP QACE NWLR GKNR MDVF SQNM FCAG HPSL KQDA CQGD SGGV FAVR DPNT DRWV ATGI VSWG IGCS RGYG FYTK VLNY VDWI KKEM EEED
Gene ID:715
Uniprot:P00736
Cellular Location:
Calculated MW:80kDa
Observed MW:80kDa
Synonyms:C1R, EDSPD1
Background:
UniProt Protein Function:C1R: C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. Belongs to the peptidase S1 family.
UniProt Protein Details:

Protein type:EC 3.4.21.41; Protease

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: extracellular region

Molecular Function:protein binding; serine-type peptidase activity; serine-type endopeptidase activity; calcium ion binding

Biological Process: innate immune response; immune response; proteolysis; complement activation, classical pathway; complement activation

Disease: Complement Component C1r/c1s Deficiency

UniProt Code:P00736
NCBI GenInfo Identifier:218511956
NCBI Gene ID:715
NCBI Accession:P00736.2
UniProt Secondary Accession:P00736,Q68D77, Q8J012, A6NJQ8,
UniProt Related Accession:P00736
Molecular Weight:705
NCBI Full Name:Complement C1r subcomponent
NCBI Synonym Full Names:complement component 1, r subcomponent
NCBI Official Symbol:C1R  
NCBI Protein Information:complement C1r subcomponent
UniProt Protein Name:Complement C1r subcomponent
UniProt Synonym Protein Names:Complement component 1 subcomponent rCleaved into the following 2 chains:Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain
Protein Family:Complement C1r subcomponent
UniProt Gene Name:C1R  
UniProt Entry Name:C1R_HUMAN
Anti-C1R Antibody (CAB15650)Western blot analysis of extracts of various cell lines, using C1R antibody (CAB15650) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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