Description
| Antibody Name: | Anti-C1QA Antibody |
| Antibody SKU: | CAB1821 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-245 of human C1QA (NP_057075.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse lung, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-245 of human C1QA (NP_057075.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EDLC RAPD GKKG EAGR PGRR GRPG LKGE QGEP GAPG IRTG IQGL KGDQ GEPG PSGN PGKV GYPG PSGP LGAR GIPG IKGT KGSP GNIK DQPR PAFS AIRR NPPM GGNV VIFD TVIT NQEE PYQN HSGR FVCT VPGY YYFT FQVL SQWE ICLS IVSS SRGQ VRRS LGFC DTTN KGLF QVVS GGMV LQLQ QGDQ VWVE KDPK KGHI YQGS EADS VFSG FLIF PSA |
| Gene ID: | 712 |
| Uniprot: | P02745 |
| Cellular Location: | Secreted |
| Calculated MW: | 26kDa |
| Observed MW: | 25kDa |
| Synonyms: | C1QA |
| Background: | This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q. |
| UniProt Protein Function: | C1QA iso2: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2 )-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 1p36.12 Cellular Component: complement component C1 complex; extracellular region Molecular Function:protein binding; serine-type endopeptidase activity Biological Process: cell-cell signaling; complement activation; complement activation, classical pathway Disease: C1q Deficiency |
| NCBI Summary: | This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P02745 |
| NCBI GenInfo Identifier: | 399138 |
| NCBI Gene ID: | 712 |
| NCBI Accession: | P02745.2 |
| UniProt Secondary Accession: | P02745,Q5T963, B2R4X2, |
| UniProt Related Accession: | P02745 |
| Molecular Weight: | 26,017 Da |
| NCBI Full Name: | Complement C1q subcomponent subunit A |
| NCBI Synonym Full Names: | complement C1q A chain |
| NCBI Official Symbol: | C1QA |
| NCBI Protein Information: | complement C1q subcomponent subunit A |
| UniProt Protein Name: | Complement C1q subcomponent subunit A |
| Protein Family: | Complement C1q subcomponent |
| UniProt Gene Name: | C1QA |
| UniProt Entry Name: | C1QA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using C1QA Antibody (CAB1821) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). |
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Additional Information
Product Type: |
Antibody |
Reactivity: |
Mouse |
Host Species: |
Rabbit |
Isotype: |
IgG |
Research Area: |
Immunology |
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