Epigenetics & Nuclear Signaling Antibodies 2
Anti-C11orf30 Antibody (CAB6138)
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- SKU:
- CAB6138
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-C11orf30 Antibody |
| Antibody SKU: | CAB6138 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1153-1322 of human C11orf30 (NP_064578.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse lung, Mouse brain, Mouse spleen, Mouse ovary, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1153-1322 of human C11orf30 (NP_064578.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SLME AQID TNVE HMIV DPPK KALA TSML TGEA GSLP STHM VVAG MANS TPQQ QKCR ESCS SPST VGSS LTTR KIDP PAVP ATGQ FMRI QNVG QKKA EESP AEII IQAI PQYA IPCH SSSN VVVE PSGL LELN NFTS QQLD DEET AMEQ DIDS STED GTEP SPSQ SSAE RS |
| Gene ID: | 56946 |
| Uniprot: | Q7Z589 |
| Cellular Location: | Nucleus |
| Calculated MW: | 9kDa/123kDa/131kDa/141kDa/143kDa |
| Observed MW: | 100kDa |
| Synonyms: | EMSY, C11orf30, GL002 |
| Background: |
| UniProt Protein Function: | EMSY: Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription regulation; DNA repair, damage Chromosomal Location of Human Ortholog: 11q13.5 Cellular Component: nucleoplasm Molecular Function:protein binding |
| UniProt Code: | Q7Z589 |
| NCBI GenInfo Identifier: | 47605660 |
| NCBI Gene ID: | 56946 |
| NCBI Accession: | Q7Z589.2 |
| UniProt Secondary Accession: | Q7Z589,Q17RM7, Q4G109, Q8NBU6, Q8TE50, Q9H8I9, Q9NRH0 B7ZKT8, B7ZKU0, B7ZKU2, |
| UniProt Related Accession: | Q7Z589 |
| Molecular Weight: | 143,193 Da |
| NCBI Full Name: | BRCA2-interacting transcriptional repressor EMSY |
| NCBI Synonym Full Names: | EMSY, BRCA2 interacting transcriptional repressor |
| NCBI Official Symbol: | EMSY |
| NCBI Official Synonym Symbols: | GL002; C11orf30 |
| NCBI Protein Information: | BRCA2-interacting transcriptional repressor EMSY |
| UniProt Protein Name: | BRCA2-interacting transcriptional repressor EMSY |
| Protein Family: | BRCA2-interacting transcriptional repressor |
| UniProt Gene Name: | EMSY |
| UniProt Entry Name: | EMSY_HUMAN |
 | Western blot analysis of extracts of various cell lines, using C11orf30 antibody (CAB6138) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of U2OS cells using C11orf30 antibody (CAB6138). |
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