Cardiovascular Antibodies

Anti-C1 Inactivator Antibody (CAB1717)

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SKU:
CAB1717
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cardiovascular

Description

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Antibody Name:Anti-C1 Inactivator Antibody
Antibody SKU:CAB1717
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 201-500 of human C1 Inactivator (NP_001027466.1).
Application:WB IF
Recommended Dilution:WB 1:1000 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:DU145, SKOV3, HeLa, LO2, U-251MG, Mouse liver, Mouse lung, Rat heart, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 201-500 of human C1 Inactivator (NP_001027466.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KDFT CVHQ ALKG FTTK GVTS VSQI FHSP DLAI RDTF VNAS RTLY SSSP RVLS NNSD ANLE LINT WVAK NTNN KISR LLDS LPSD TRLV LLNA IYLS AKWK TTFD PKKT RMEP FHFK NSVI KVPM MNSK KYPV AHFI DQTL KAKV GQLQ LSHN LSLV ILVP QNLK HRLE DMEQ ALSP SVFK AIME KLEM SKFQ PTLL TLPR IKVT TSQD MLSI MEKL EFFD FSYD LNLC GLTE DPDL QVSA MQHQ TVLE LTET GVEA AAAS AISV ARTL LVFE VQQP FLFV LWDQ QHKF PVFM GRVY DPRA
Gene ID:710
Uniprot:P05155
Cellular Location:Secreted
Calculated MW:49kDa/55kDa
Observed MW:60kDa.110kDa
Synonyms:SERPING1, C1IN, C1INH, C1NH, HAE1, HAE2
Background:This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform.
UniProt Protein Function:SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: extracellular space; extracellular region

Molecular Function:serine-type endopeptidase inhibitor activity; protein binding

Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; fibrinolysis; platelet degranulation; blood circulation; innate immune response; blood coagulation; complement activation, classical pathway; blood coagulation, intrinsic pathway; aging

Disease: Complement Component 4, Partial Deficiency Of; Angioedema, Hereditary, Type I

NCBI Summary:This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]
UniProt Code:P05155
NCBI GenInfo Identifier:124096
NCBI Gene ID:710
NCBI Accession:P05155.2
UniProt Secondary Accession:P05155,Q16304, Q547W3, Q59EI5, Q7Z455, Q96FE0, Q9UC49 A6NMU0, A8KAI9, B2R6L5, B4E1F0, B4E1H2,
UniProt Related Accession:P05155
Molecular Weight:
NCBI Full Name:Plasma protease C1 inhibitor
NCBI Synonym Full Names:serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
NCBI Official Symbol:SERPING1  
NCBI Official Synonym Symbols:C1IN; C1NH; HAE1; HAE2; C1INH  
NCBI Protein Information:plasma protease C1 inhibitor; serpin G1; C1-inhibiting factor; C1 esterase inhibitor; complement component 1 inhibitor; serine/cysteine proteinase inhibitor clade G member 1
UniProt Protein Name:Plasma protease C1 inhibitor
UniProt Synonym Protein Names:C1 esterase inhibitor; C1-inhibiting factor; Serpin G1
Protein Family:Para-Rep
UniProt Gene Name:SERPING1  
UniProt Entry Name:IC1_HUMAN
Anti-C1 Inactivator Antibody (CAB1717)Western blot analysis of extracts of various cell lines, using C1 Inactivator antibody (CAB1717) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s.
Anti-C1 Inactivator Antibody (CAB1717)Immunofluorescence analysis of C6 cells using C1 Inactivator antibody ( A1717) at dilution of 1:100. Blue: DAPI for nuclear staining.
Anti-C1 Inactivator Antibody (CAB1717)Immunofluorescence analysis of HeLa cells using C1 Inactivator antibody ( A1717) at dilution of 1:100. Blue: DAPI for nuclear staining.
Anti-C1 Inactivator Antibody (CAB1717)Immunofluorescence analysis of NIH/3T3 cells using C1 Inactivator antibody ( A1717) at dilution of 1:100. Blue: DAPI for nuclear staining.
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