Cardiovascular Antibodies
Anti-C1 Inactivator Antibody (CAB12407)
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- SKU:
- CAB12407
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-C1 Inactivator Antibody |
| Antibody SKU: | CAB12407 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 201-500 of human C1 Inactivator (NP_001027466.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 201-500 of human C1 Inactivator (NP_001027466.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KDFT CVHQ ALKG FTTK GVTS VSQI FHSP DLAI RDTF VNAS RTLY SSSP RVLS NNSD ANLE LINT WVAK NTNN KISR LLDS LPSD TRLV LLNA IYLS AKWK TTFD PKKT RMEP FHFK NSVI KVPM MNSK KYPV AHFI DQTL KAKV GQLQ LSHN LSLV ILVP QNLK HRLE DMEQ ALSP SVFK AIME KLEM SKFQ PTLL TLPR IKVT TSQD MLSI MEKL EFFD FSYD LNLC GLTE DPDL QVSA MQHQ TVLE LTET GVEA AAAS AISV ARTL LVFE VQQP FLFV LWDQ QHKF PVFM GRVY DPRA |
| Gene ID: | 710 |
| Uniprot: | P05155 |
| Cellular Location: | Secreted |
| Calculated MW: | 49kDa/55kDa |
| Observed MW: | 60kDa |
| Synonyms: | SERPING1, C1IN, C1INH, C1NH, HAE1, HAE2 |
| Background: | This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. |
| UniProt Protein Function: | SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 11q12.1 Cellular Component: extracellular space; extracellular region Molecular Function:serine-type endopeptidase inhibitor activity; protein binding Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; fibrinolysis; platelet degranulation; blood circulation; innate immune response; blood coagulation; complement activation, classical pathway; blood coagulation, intrinsic pathway; aging Disease: Complement Component 4, Partial Deficiency Of; Angioedema, Hereditary, Type I |
| NCBI Summary: | This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P05155 |
| NCBI GenInfo Identifier: | 124096 |
| NCBI Gene ID: | 710 |
| NCBI Accession: | P05155.2 |
| UniProt Secondary Accession: | P05155,Q16304, Q547W3, Q59EI5, Q7Z455, Q96FE0, Q9UC49 A6NMU0, A8KAI9, B2R6L5, B4E1F0, B4E1H2, |
| UniProt Related Accession: | P05155 |
| Molecular Weight: | |
| NCBI Full Name: | Plasma protease C1 inhibitor |
| NCBI Synonym Full Names: | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 |
| NCBI Official Symbol: | SERPING1 |
| NCBI Official Synonym Symbols: | C1IN; C1NH; HAE1; HAE2; C1INH |
| NCBI Protein Information: | plasma protease C1 inhibitor; serpin G1; C1-inhibiting factor; C1 esterase inhibitor; complement component 1 inhibitor; serine/cysteine proteinase inhibitor clade G member 1 |
| UniProt Protein Name: | Plasma protease C1 inhibitor |
| UniProt Synonym Protein Names: | C1 esterase inhibitor; C1-inhibiting factor; Serpin G1 |
| Protein Family: | Para-Rep |
| UniProt Gene Name: | SERPING1 |
| UniProt Entry Name: | IC1_HUMAN |
 | Western blot analysis of extracts of mouse heart, using C1 Inactivator Antibody (CAB12407) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded rat kidney using C1 Inactivator antibody (CAB12407) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human breast cancer using C1 Inactivator antibody (CAB12407) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse liver using C1 Inactivator antibody (CAB12407) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using C1 Inactivator antibody (CAB12407) at dilution of 1:100 (40x lens). |
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