Anti-Butyrylcholinesterase Antibody (CAB8861)

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SKU:
CAB8861
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CHE1
Synonyms:
CHE2
Synonyms:
E1
Research Area:
Cell Biology

Description

Product Name:Butyrylcholinesterase Rabbit mAb
Product Code:CAB8861
Size:20uL, 50uL, 100uL
Synonyms:CHE1, CHE2, E1
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Butyrylcholinesterase
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa
Immunogen:A synthesized peptide derived from human Butyrylcholinesterase
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:590
Uniprot:P06276
Calculated MW:90kDa
Observed MW:90KDa
UniProt Protein Function:BCHE: Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency). BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait. Belongs to the type-B carboxylesterase/lipase family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Hydrolase; Nuclear envelope; Secreted; EC 3.1.1.8

Chromosomal Location of Human Ortholog: 3q26.1-q26.2

Cellular Component: membrane; nuclear envelope lumen; endoplasmic reticulum lumen; extracellular region

Molecular Function:identical protein binding; choline binding; enzyme binding; cholinesterase activity; beta-amyloid binding; acetylcholinesterase activity; catalytic activity

Biological Process: response to drug; response to alkaloid; negative regulation of cell proliferation; choline metabolic process; cocaine metabolic process; cellular protein metabolic process; response to folic acid; response to glucocorticoid stimulus; neuroblast differentiation; learning; negative regulation of synaptic transmission

NCBI Summary:This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. The encoded enzyme exhibits broad substrate specificity and is involved in the detoxification of poisons including organophosphate nerve agents and pesticides, and the metabolism of drugs including cocaine, heroin and aspirin. Humans homozygous for certain mutations in this gene exhibit prolonged apnea after administration of the muscle relaxant succinylcholine. [provided by RefSeq, Jul 2016]
UniProt Code:P06276
NCBI GenInfo Identifier:116353
NCBI Gene ID:590
NCBI Accession:P06276.1
UniProt Related Accession:P06276
Molecular Weight:
NCBI Full Name:Cholinesterase
NCBI Synonym Full Names:butyrylcholinesterase
NCBI Official Symbol:BCHE  
NCBI Official Synonym Symbols:E1; CHE1; CHE2; BCHED  
NCBI Protein Information:cholinesterase
UniProt Protein Name:Cholinesterase
UniProt Synonym Protein Names:Acylcholine acylhydrolase; Butyrylcholine esterase; Choline esterase II; Pseudocholinesterase
Protein Family:Cholinesterase
UniProt Gene Name:BCHE  
UniProt Entry Name:CHLE_HUMAN
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