Immunology Antibodies 1
Anti-BTK Antibody (CAB12738)
- SKU:
- CAB12738
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Antibody Name: | Anti-BTK Antibody |
Antibody SKU: | CAB12738 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 173-272 of human BTK (NP_000052.1). |
Application: | WB IHC |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | BT-474, Mouse lung, Rat lung, Rat liver |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 173-272 of human BTK (NP_000052.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | GSLK PGSS HRKT KKPL PPTP EEDQ ILKK PLPP EPAA APVS TSEL KKVV ALYD YMPM NAND LQLR KGDE YFIL EESN LPWW RARD KNGQ EGYI PSNY VTEA |
Gene ID: | 695 |
Uniprot: | Q06187 |
Cellular Location: | Cell membrane, Cytoplasm, Nucleus, Peripheral membrane protein |
Calculated MW: | 76kDa/79kDa |
Observed MW: | 76kDa |
Synonyms: | AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA, BTK |
Background: | The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. |
UniProt Protein Function: | Btk: a tyrosine kinase of the Tec family. Plays a crucial role in B-cell ontogeny. Defects cause X-linked agammaglobulinemia, an immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. Truncated splice forms found in childhood leukemias may underlie radiation resistance of tumors through inhibition of apoptosis. |
UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, TK; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); TK group; Tec family Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; extrinsic to internal side of plasma membrane; intracellular membrane-bound organelle; lipid raft; mast cell granule; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane Molecular Function:ATP binding; identical protein binding; kinase activity; lipid binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphatidylinositol-3,4,5-triphosphate binding; protein binding; protein kinase activity; protein-tyrosine kinase activity; transferase activity Biological Process: adaptive immune response; apoptosis; cell maturation; histamine secretion by mast cell; I-kappaB kinase/NF-kappaB cascade; immune system process; innate immune response; negative regulation of cytokine production; peptidyl-tyrosine phosphorylation; phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; regulation of transcription, DNA-dependent; response to organic substance; transcription, DNA-dependent; transmembrane receptor protein tyrosine kinase signaling pathway |
NCBI Summary: | The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013] |
UniProt Code: | Q06187 |
NCBI GenInfo Identifier: | 547759 |
NCBI Gene ID: | 695 |
NCBI Accession: | Q06187.3 |
UniProt Secondary Accession: | Q06187,Q61365, |
UniProt Related Accession: | Q06187 |
Molecular Weight: | |
NCBI Full Name: | Tyrosine-protein kinase BTK |
NCBI Synonym Full Names: | Bruton tyrosine kinase |
NCBI Official Symbol: | BTK |
NCBI Official Synonym Symbols: | AT; ATK; BPK; XLA; IMD1; AGMX1; PSCTK1 |
NCBI Protein Information: | tyrosine-protein kinase BTK |
UniProt Protein Name: | Tyrosine-protein kinase BTK |
UniProt Synonym Protein Names: | Agammaglobulinemia tyrosine kinase; ATK; B-cell progenitor kinase; BPK; Bruton tyrosine kinase; Kinase EMB |
Protein Family: | Tyrosine-protein kinase |
UniProt Gene Name: | Btk |
UniProt Entry Name: | BTK_MOUSE |