Cell Cycle Antibodies 1

Anti-BRINP1 Antibody (CAB11723)

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SKU:
CAB11723
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-BRINP1 Antibody
Antibody SKU:CAB11723
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human BRINP1 (NP_055433.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:U-87MG
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human BRINP1 (NP_055433.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VQPS HQEP AGTD QHVS KEFD WLIS DRGP FHHS RSYL SFVE RHRQ GFTT RYKI YREF ARWK VRNT AIER RDLV RHPV PLMP EFQR SIRL LGRR PTTQ QFID TIIK KYGT HLLI SATL GGEE ALTM YMDK SRLD RKSG NATQ SVEA LHQL ASSY FVDR DGTM RRLH EIQI STGA IKVT ETRT GPLG CNSY DNLD SVSS VLLQ STES KLHL QGLQ IIFP QYLQ EKFV QSAL SYIM CNGE GEYL CQNS QCRC QCAE EFPQ CNCP ITDI QIME YTLA NMAK SWAE A
Gene ID:1620
Uniprot:O60477
Cellular Location:Cytoplasm
Calculated MW:37kDa/55kDa/88kDa
Observed MW:105kDa
Synonyms:BRINP1, DBC1, DBCCR1, FAM5A
Background:This gene is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.
UniProt Protein Function:DBC1: Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway. Belongs to the FAM5 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 9q32-q33

Cellular Component: cytoplasm

Molecular Function:protein binding

Biological Process: cell death; negative regulation of cell cycle

NCBI Summary:This gene is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers. [provided by RefSeq, Jul 2008]
UniProt Code:O60477
NCBI GenInfo Identifier:85700960
NCBI Gene ID:1620
NCBI Accession:O60477.2
UniProt Secondary Accession:O60477,Q6IPV6, Q6P1A0, Q8WU22,
UniProt Related Accession:O60477
Molecular Weight:55,671 Da
NCBI Full Name:BMP/retinoic acid-inducible neural-specific protein 1
NCBI Synonym Full Names:BMP/retinoic acid inducible neural specific 1
NCBI Official Symbol:BRINP1  
NCBI Official Synonym Symbols:DBC1; FAM5A; DBCCR1  
NCBI Protein Information:BMP/retinoic acid-inducible neural-specific protein 1
UniProt Protein Name:BMP/retinoic acid-inducible neural-specific protein 1
UniProt Synonym Protein Names:Deleted in bladder cancer protein 1
Protein Family:BMP/retinoic acid-inducible neural-specific protein
UniProt Gene Name:BRINP1  
UniProt Entry Name:BRNP1_HUMAN
Anti-BRINP1 Antibody (CAB11723)Western blot analysis of extracts of U-87MG cells, using BRINP1 antibody (CAB11723) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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