Cell Biology Antibodies 10
Anti-BMP3 Antibody (CAB6877)
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- SKU:
- CAB6877
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-BMP3 Antibody |
| Antibody SKU: | CAB6877 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 243-472 of human BMP3 (NP_001192.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW480, Mouse ovary, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 243-472 of human BMP3 (NP_001192.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YAND AAIS EPES VVSS LQGH RNFP TGTV PKWD SHIR AALS IERR KKRS TGVL LPLQ NNEL PGAE YQYK KDEV WEER KPYK TLQA QAPE KSKN KKKQ RKGP HRKS QTLQ FDEQ TLKK ARRK QWIE PRNC ARRY LKVD FADI GWSE WIIS PKSF DAYY CSGA CQFP MPKS LKPS NHAT IQSI VRAV GVVP GIPE PCCV PEKM SSLS ILFF DENK NVVL KVYP NMTV ESCA CR |
| Gene ID: | 651 |
| Uniprot: | P12645 |
| Cellular Location: | Secreted |
| Calculated MW: | 53kDa |
| Observed MW: | 53kDa |
| Synonyms: | BMP3, BMP-3A |
| Background: | BMP3 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein, also known as osteogenin, induces bone formation. |
| UniProt Protein Function: | BMP3: Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Cytokine Chromosomal Location of Human Ortholog: 4q21 Cellular Component: extracellular space Molecular Function:cytokine activity; receptor binding; transforming growth factor beta receptor binding Biological Process: BMP signaling pathway; cell development; cell-cell signaling; regulation of apoptosis; regulation of MAPKKK cascade; skeletal development |
| NCBI Summary: | BMP3 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein, also known as osteogenin, induces bone formation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P12645 |
| NCBI GenInfo Identifier: | 215273985 |
| NCBI Gene ID: | 651 |
| NCBI Accession: | P12645.2 |
| UniProt Secondary Accession: | P12645,Q4VAS5, |
| UniProt Related Accession: | P12645 |
| Molecular Weight: | 53,372 Da |
| NCBI Full Name: | Bone morphogenetic protein 3 |
| NCBI Synonym Full Names: | bone morphogenetic protein 3 |
| NCBI Official Symbol: | BMP3 |
| NCBI Official Synonym Symbols: | BMP-3A |
| NCBI Protein Information: | bone morphogenetic protein 3 |
| UniProt Protein Name: | Bone morphogenetic protein 3 |
| UniProt Synonym Protein Names: | Bone morphogenetic protein 3A; BMP-3A; Osteogenin |
| Protein Family: | Bone morphogenetic protein |
| UniProt Gene Name: | BMP3 |
| UniProt Entry Name: | BMP3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using BMP3 antibody (CAB6877) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded rat kidney using BMP3 antibody (CAB6877) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat heart using BMP3 antibody (CAB6877) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using BMP3 antibody (CAB6877) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse heart using BMP3 antibody (CAB6877) at dilution of 1:100 (40x lens). |
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