| UniProt Protein Function: | BMI1: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. Component of a PRC1-like complex. Interacts with RING1 and RING2. Interacts vwith CBX7 and CBX8. Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP. Interacts with E4F1. |
| UniProt Protein Details: | Protein type:Ubiquitin ligase; Ubiquitin conjugating system; Ligase; EC 6.3.2.-; Oncoprotein; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 10p11.23 Cellular Component: nucleoplasm; heterochromatin; nuclear body; cytoplasm; PcG protein complex; nucleus; ubiquitin ligase complex Molecular Function:protein binding; zinc ion binding; sequence-specific DNA binding; ubiquitin-protein ligase activity; chromatin binding Biological Process: transcription, DNA-dependent; in utero embryonic development; positive regulation of immature T cell proliferation in the thymus; negative regulation of transcription from RNA polymerase II promoter; humoral immune response; embryonic skeletal morphogenesis; segment specification; rostrocaudal neural tube patterning; positive regulation of fibroblast proliferation; regulation of gene expression; positive regulation of ubiquitin-protein ligase activity; histone ubiquitination; positive regulation of B cell proliferation; DNA methylation; somatic stem cell division; hemopoiesis; histone acetylation; brain development |
| NCBI Summary: | This locus represents naturally occurring read-through transcription between the neighboring COMM domain-containing protein 3 and polycomb complex protein BMI-1 genes on chromosome 10. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011] |
| UniProt Code: | P35226 |
| NCBI GenInfo Identifier: | 22258801 |
| NCBI Gene ID: | 100532731 |
| NCBI Accession: | P35226.2 |
| UniProt Secondary Accession: | P35226,Q16030, Q5T8Z3, Q96F37, |
| Molecular Weight: | 36,949 Da |
| NCBI Full Name: | Polycomb complex protein BMI-1 |
| NCBI Synonym Full Names: | COMMD3-BMI1 readthrough |
| NCBI Official Symbol: | COMMD3-BMI1 |
| NCBI Protein Information: | COMMD3-BMI1 read-through protein |
| UniProt Protein Name: | Polycomb complex protein BMI-1 |
| UniProt Synonym Protein Names: | Polycomb group RING finger protein 4; RING finger protein 51 |
| Protein Family: | Polycomb complex protein |
| UniProt Gene Name: | BMI1 |
| UniProt Entry Name: | BMI1_HUMAN |
