Cell Biology Antibodies 11
Anti-BLK Antibody (CAB7427)
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- SKU:
- CAB7427
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-BLK Antibody |
| Antibody SKU: | CAB7427 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human BLK (NP_001706.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, Mouse spleen, Mouse brain, Rat spleen, Rat brain, Mouse thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human BLK (NP_001706.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGLV SSKK PDKE KPIK EKDK GQWS PLKV SAQD KDAP PLPP LVVF NHLT PPPP DEHL DEDK HFVV ALYD YTAM NDRD LQML KGEK LQVL KGTG DWWL ARSL VTGR EGYV PSNF VARV ESLE MERW FFRS QGRK EAER QLLA PINK AGSF LIRE SETN KGAF SLSV KDVT TQGE LIKH YKIR CLDE GGYY ISPR ITFP SLQA LVQH YSKK GDGL CQRL TLPC VRPA PQNP WAQD EWEI PRQS |
| Gene ID: | 640 |
| Uniprot: | P51451 |
| Cellular Location: | Cell membrane, Lipid-anchor |
| Calculated MW: | 57kDa |
| Observed MW: | 58kDa |
| Synonyms: | BLK, MODY11 |
| Background: | This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. |
| UniProt Protein Function: | BLK: a nonreceptor tyrosine kinase of the Src family. Expressed predominantly in B lymphocytes |
| UniProt Protein Details: | Protein type:Protein kinase, TK; Kinase, protein; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); TK group; Src family Chromosomal Location of Human Ortholog: 8p23-p22 Cellular Component: extrinsic to internal side of plasma membrane Molecular Function:protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding Biological Process: B cell receptor signaling pathway; innate immune response; positive regulation of insulin secretion; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation; T cell differentiation Disease: Maturity-onset Diabetes Of The Young, Type 11 |
| NCBI Summary: | This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010] |
| UniProt Code: | P51451 |
| NCBI GenInfo Identifier: | 158936749 |
| NCBI Gene ID: | 640 |
| NCBI Accession: | P51451.3 |
| UniProt Secondary Accession: | P51451,Q16291, Q96IN1, |
| UniProt Related Accession: | P51451 |
| Molecular Weight: | 505 |
| NCBI Full Name: | Tyrosine-protein kinase Blk |
| NCBI Synonym Full Names: | BLK proto-oncogene, Src family tyrosine kinase |
| NCBI Official Symbol: | BLK |
| NCBI Official Synonym Symbols: | MODY11 |
| NCBI Protein Information: | tyrosine-protein kinase Blk; p55-Blk; b lymphocyte kinase; B lymphoid tyrosine kinase; BLK nonreceptor tyrosine kinase |
| UniProt Protein Name: | Tyrosine-protein kinase Blk |
| UniProt Synonym Protein Names: | B lymphocyte kinase; p55-Blk |
| Protein Family: | Tyrosine-protein kinase |
| UniProt Gene Name: | BLK |
| UniProt Entry Name: | BLK_HUMAN |
 | Western blot analysis of extracts of various cell lines, using BLK Antibody (CAB7427) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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