Epigenetics & Nuclear Signaling Antibodies 1
Anti-BICD2 Antibody (CAB10292)
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- SKU:
- CAB10292
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-BICD2 Antibody |
| Antibody SKU: | CAB10292 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 440-620 of human BICD2 (NP_001003800.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, HL-60, HeLa, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 440-620 of human BICD2 (NP_001003800.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HVAV AEAG ELRE QLKA LRST HEAR EAQH AEEK GRYE AEGQ ALTE KVSL LEKA SRQD RELL ARLE KELK KVSD VAGE TQGS LSVA QDEL VTFS EELA NLYH HVCM CNNE TPNR VMLD YYRE GQGG AGRT SPGG RTSP EARG RRSP ILLP KGLL APEA GRAD GGTG DSSP SPGS SLPS PLSD P |
| Gene ID: | 23299 |
| Uniprot: | Q8TD16 |
| Cellular Location: | Cytoplasm, Golgi apparatus, cytoskeleton |
| Calculated MW: | 93kDa/96kDa |
| Observed MW: | 118kDa |
| Synonyms: | BICD2, SMALED2, bA526D8.1 |
| Background: | This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described. |
| UniProt Protein Function: | BICD2: May play a role in the dynein-dynactin interactions on the surface of membranous organelles, by associating with these complexes. Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex. Belongs to the BicD family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 9q22.31 Cellular Component: annulate lamellae; cytoplasmic vesicle; cytosol; Golgi apparatus; nuclear envelope; nuclear pore; plasma membrane Molecular Function:protein binding; Rab GTPase binding Biological Process: centrosome localization; protein targeting to Golgi; retrograde vesicle-mediated transport, Golgi to ER Disease: Spinal Muscular Atrophy, Lower Extremity-predominant, 2, Autosomal Dominant |
| NCBI Summary: | This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8TD16 |
| NCBI GenInfo Identifier: | 34098604 |
| NCBI Gene ID: | 23299 |
| NCBI Accession: | Q8TD16.1 |
| UniProt Secondary Accession: | Q8TD16,O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561 |
| UniProt Related Accession: | Q8TD16 |
| Molecular Weight: | 94kDa |
| NCBI Full Name: | Protein bicaudal D homolog 2 |
| NCBI Synonym Full Names: | BICD cargo adaptor 2 |
| NCBI Official Symbol: | BICD2 |
| NCBI Official Synonym Symbols: | SMALED2; bA526D8.1 |
| NCBI Protein Information: | protein bicaudal D homolog 2 |
| UniProt Protein Name: | Protein bicaudal D homolog 2 |
| Protein Family: | Protein bicaudal |
| UniProt Gene Name: | BICD2 |
 | Western blot analysis of extracts of various cell lines, using BICD2 antibody (CAB10292) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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