Cell Biology Antibodies 2
Anti-BHLHE41 Antibody (CAB10555)
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- SKU:
- CAB10555
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-BHLHE41 Antibody |
| Antibody SKU: | CAB10555 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-280 of human BHLHE41 (NP_110389.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | NCI-H460, Mouse skeletal muscle, Mouse brain, Mouse lung, Rat skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-280 of human BHLHE41 (NP_110389.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LKSP IQSD LDAF HSGF QTCA KEVL QYLS RFES WTPR EPRC VQLI NHLH AVAT QFLP TPQL LTQQ VPLS KGTG APSA AGSA AAPC LERA GQKL EPLA YCVP VIQR TQPS AELA AEND TDTD SGYG GEAE ARPD REKG KGAG ASRV TIKQ EPPG EDSP APKR M |
| Gene ID: | 79365 |
| Uniprot: | Q9C0J9 |
| Cellular Location: | Nucleus |
| Calculated MW: | 50kDa |
| Observed MW: | 50kDa |
| Synonyms: | BHLHE41, BHLHB3, DEC2, SHARP1, hDEC2 |
| Background: | This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype. |
| UniProt Protein Function: | BHLHB3: May be a transcriptional repressor that represses both basal and activated transcription. Homodimerize. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 12p12.1 Molecular Function:bHLH transcription factor binding; histone deacetylase binding; MRF binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; transcription corepressor activity Biological Process: negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent Disease: Short Sleeper |
| NCBI Summary: | This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype. [provided by RefSeq, Feb 2014] |
| UniProt Code: | Q9C0J9 |
| NCBI GenInfo Identifier: | 20137459 |
| NCBI Gene ID: | 79365 |
| NCBI Accession: | Q9C0J9.1 |
| UniProt Secondary Accession: | Q9C0J9,A2I2N8, |
| UniProt Related Accession: | Q9C0J9 |
| Molecular Weight: | 50kDa |
| NCBI Full Name: | Class E basic helix-loop-helix protein 41 |
| NCBI Synonym Full Names: | basic helix-loop-helix family member e41 |
| NCBI Official Symbol: | BHLHE41 |
| NCBI Official Synonym Symbols: | DEC2; hDEC2; BHLHB3; SHARP1 |
| NCBI Protein Information: | class E basic helix-loop-helix protein 41 |
| UniProt Protein Name: | Class E basic helix-loop-helix protein 41 |
| UniProt Synonym Protein Names: | Class B basic helix-loop-helix protein 3; bHLHb3; Differentially expressed in chondrocytes protein 2; hDEC2; Enhancer-of-split and hairy-related protein 1; SHARP-1 |
| Protein Family: | Class E basic helix-loop-helix protein |
| UniProt Gene Name: | BHLHE41 |
 | Western blot analysis of extracts of various cell lines, using BHLHE41 antibody (CAB10555) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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