Cell Biology Antibodies 12
Anti-Beta-chimaerin Antibody (CAB9343)
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- SKU:
- CAB9343
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Beta-chimaerin Antibody |
| Antibody SKU: | CAB9343 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CHN2 (NP_004058.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | U-251MG, 293T, SW620, Mouse brain, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CHN2 (NP_004058.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAS SNSS LSGS SVSS DAEE YQPP IWKS YLYQ LQQE APRP KRII CPRE VENR PKYY GREF HGII SREQ ADEL LGGV EGAY ILRE SQRQ PGCY TLAL RFGN QTLN YRLF HDGK HFVG EKRF ESIH DLVT DGLI TLYI ETKA AEYI SKMT TNPI YEHI GYAT LLRE KVSR RLSR SKNE PRKT NVTH EEHT AVEK ISSL VRRA |
| Gene ID: | 1124 |
| Uniprot: | P52757 |
| Cellular Location: | Membrane, Peripheral membrane protein |
| Calculated MW: | 27kDa/31kDa/33kDa/37kDa/38kDa/53kDa/62kDa |
| Observed MW: | 54kDa |
| Synonyms: | CHN2, ARHGAP3, BCH, CHN2-3, RHOGAP3 |
| Background: | This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. |
| UniProt Protein Function: | ARHGAP3: GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GAPs, Rac/Rho; GAPs Chromosomal Location of Human Ortholog: 7p15.3 Cellular Component: cytoplasm; cytosol; membrane Molecular Function:GTPase activator activity; metal ion binding; protein binding; SH3/SH2 adaptor activity Biological Process: positive regulation of GTPase activity; positive regulation of signal transduction; regulation of small GTPase mediated signal transduction |
| NCBI Summary: | This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014] |
| UniProt Code: | P52757 |
| NCBI GenInfo Identifier: | 2506455 |
| NCBI Gene ID: | 1124 |
| NCBI Accession: | P52757.2 |
| UniProt Secondary Accession: | P52757,Q2M203, Q75MM2, A4D1A2, B3VCF1, B3VCF2, B3VCF3 B3VCF7, B3VCG1, C9J7B0, E9PGE0, F8QPL9, |
| UniProt Related Accession: | P52757 |
| Molecular Weight: | 62,441 Da |
| NCBI Full Name: | Beta-chimaerin |
| NCBI Synonym Full Names: | chimerin 2 |
| NCBI Official Symbol: | CHN2 |
| NCBI Official Synonym Symbols: | BCH; CHN2-3; ARHGAP3; RHOGAP3 |
| NCBI Protein Information: | beta-chimaerin |
| UniProt Protein Name: | Beta-chimaerin |
| UniProt Synonym Protein Names: | Beta-chimerin; Rho GTPase-activating protein 3 |
| Protein Family: | Beta-chimaerin |
| UniProt Gene Name: | CHN2 |
| UniProt Entry Name: | CHIO_HUMAN |
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