Cell Biology Antibodies 9

Anti-BCO2 Antibody (CAB5034)

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SKU:
CAB5034
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
BCO2
Synonyms:
B-DIOX-II
Synonyms:
BCDO2
Research Area:
Cell Biology

Description

Product Name:BCO2 Rabbit pAb
Product Code:CAB5034
Size:20uL, 50uL, 100uL
Synonyms:BCO2, B-DIOX-II, BCDO2
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 170-410 of human BCO2 (NP_001243327.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:SGC-7901, LO2, 293T, Hela, U-87MG, Mouse liver, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 170-410 of human BCO2 (NP_001243327.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KAAG FSYK VIRV PPEK VDLG ETIH GVQV ICSI ASTE KGKP SYYH SFGM TRNY IIFI EQPL KMNL WKIA TSKI RGKA FSDG ISWE PQCN TRFH VVEK RTGQ LLPG RYYS KPFV TFHQ INAF EDQG CVII DLCC QDNG RTLE VYQL QNLR KAGE GLDQ VHNS AAKS FPRR FVLP LNVS LNAP EGDN LSPL SYTS ASAV KQAD GTIW CSHE NLHQ EDLE KEGG IEFP QIYY DRFS GKKY HFFY G
Gene ID:83875
Uniprot:Q9BYV7
Cellular Location:Mitochondrion
Calculated MW:53kDa/57kDa/60kDa/61kDa/65kDa
Observed MW:65kDa
UniProt Protein Function:BCDO2: Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects. Belongs to the carotenoid oxygenase family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 1.13.11.71; Oxidoreductase

Chromosomal Location of Human Ortholog: 11q23.1

Cellular Component: intracellular; mitochondrial matrix; mitochondrion

Molecular Function:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

Biological Process: carotene catabolic process; carotene metabolic process; carotenoid metabolic process; regulation of mitochondrial membrane potential; retinoid metabolic process

NCBI Summary:This gene encodes an enzyme which oxidizes carotenoids such as beta-carotene during the biosynthesis of vitamin A. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Code:Q9BYV7
NCBI GenInfo Identifier:308153680
NCBI Gene ID:83875
NCBI Accession:Q9BYV7.5
UniProt Secondary Accession:Q9BYV7,Q8IUS0, Q96JC8, Q96JY5, B0YIX5, B4DNC3, E9PBI8 E9PJJ1,
UniProt Related Accession:Q9BYV7
Molecular Weight:53,630 Da
NCBI Full Name:Beta,beta-carotene 9',10'-oxygenase
NCBI Synonym Full Names:beta-carotene oxygenase 2
NCBI Official Symbol:BCO2  
NCBI Official Synonym Symbols:BCDO2; B-DIOX-II  
NCBI Protein Information:beta,beta-carotene 9',10'-oxygenase
UniProt Protein Name:Beta,beta-carotene 9',10'-oxygenase
UniProt Synonym Protein Names:B-diox-II; Beta-carotene dioxygenase 2
Protein Family:Beta,beta-carotene 9',10'-oxygenase
UniProt Gene Name:BCO2  
UniProt Entry Name:BCDO2_HUMAN
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