Cell Death Antibodies 1

Bcl-XL Rabbit Polyclonal Antibody (CAB0209)

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SKU:
CAB0209
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
Reactivity:
Human, Mouse, Rat
Synonyms:
BCLX, BCL2L, Bcl-X, PPP1R52, BCL-XL/S, Bcl-XL
Research Use:
Cell Death
Frequently bought together:

Description

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Bcl-XL Antibody (CAB0209)

The Bcl-XL Antibody (CAB0209) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the BCL2L1 protein, this antibody enables accurate detection and analysis in various cell types, making it an ideal choice for investigating apoptosis and cell survival mechanisms in a research setting.BCL2L1, also known as Bcl-xL, is a critical regulator of cell survival pathways and plays a crucial role in maintaining cellular homeostasis. Dysregulation of BCL2L1 has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.

This antibody is validated for use in WB, IHC-P, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:Bcl-XL Antibody
SKU:CAB0209
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MSQS NREL VVDF LSYK LSQK GYSW SQFS DVEE NRTE APEG TESE METP SAIN GNPS WHLA DSPA VNGA TGHS SSLD AREV
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:1000
IHC-P1:50 - 1:200
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:BCLX, BCL2L, Bcl-X, PPP1R52, BCL-XL/S, Bcl-XL
Positive Sample:OVCAR3, Rat lung, Rat spleen
Cellular Localization:Cytoplasm, Cytoplasmic Side, Cytoplasmic Vesicle, Mitochondrion Inner Membrane, Mitochondrion Matrix, Mitochondrion Outer Membrane, Nucleus Membrane, Single-Pass Membrane Protein, Centrosome, Cytoskeleton, Cytosol, Microtubule Organizing Center, Secretory Vesicle, Synaptic Vesicle Membrane.
Calculated MW:26kDa
Observed MW:30kDa

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.

Purification MethodAffinity purification
Gene ID598
RRIDAB_2757023
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using Bcl-XL Rabbit pAb (CAB0209) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human liver using Bcl-XL Rabbit pAb (CAB0209) at dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M Tris/EDTA Buffer (pH 9.0) prior to IHC staining.
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