Epigenetics & Nuclear Signaling Antibodies 3
Anti-BCL11A Antibody (CAB5445)
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- SKU:
- CAB5445
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-BCL11A Antibody |
| Antibody SKU: | CAB5445 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human BCL11A (NP_060484.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | K-562, HT-29, 22Rv1, Jurkat, Raji, HeLa, A-549, Mouse spleen, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human BCL11A (NP_060484.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSRR KQGK PQHL SKRE FSPE PLEA ILTD DEPD HGPL GAPE GDHD LLTC GQCQ MNFP LGDI LIFI EHKR KQCN GSLC LEKA VDKP PSPS PIEM KKAS NPVE VGIQ VTPE DDDC LSTS SRGI CPKQ EHIA DKLL HWRG LSSP RSAH GALI PTPG MSAE YAPQ GICK DEPS SYTC TTCK QPFT SAWF LLQH AQNT HGLR IYLE SEHG SPLT PRVG IPSG LGAE CPSQ PPLH GI |
| Gene ID: | 53335 |
| Uniprot: | Q9H165 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 15kDa/26kDa/30kDa/83kDa/86kDa/87kDa/91kDa |
| Observed MW: | 113kDa |
| Synonyms: | BCL11A, BCL11A-L, BCL11A-S, BCL11A-XL, BCL11a-M, CTIP1, DILOS, EVI9, HBFQTL5, ZNF856 |
| Background: | This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. |
| UniProt Protein Function: | Bcl-11A: Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1. Chromosomal aberrations involving BCL11A may be a cause of lymphoid malignancies. Translocation t(2;14)(p13;q32.3) causes BCL11A deregulation and amplification. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; C2H2-type zinc finger protein; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 2p16.1 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:protein homodimerization activity; protein heterodimerization activity; metal ion binding; transcription corepressor activity Biological Process: protein sumoylation; transcription, DNA-dependent; B cell differentiation; regulation of dendrite development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of collateral sprouting; negative regulation of transcription from RNA polymerase II promoter; negative regulation of axon extension; positive regulation of collateral sprouting; negative regulation of protein homooligomerization; T cell differentiation |
| NCBI Summary: | This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H165 |
| NCBI GenInfo Identifier: | 20336307 |
| NCBI Gene ID: | 53335 |
| NCBI Accession: | NP_060484.2 |
| UniProt Secondary Accession: | Q9H165,Q86W14, Q8WU92, Q96JL6, Q9H163, Q9H164, Q9H3G9 Q9NWA7, D6W5D7, |
| UniProt Related Accession: | Q9H165 |
| Molecular Weight: | 91,197 Da |
| NCBI Full Name: | B-cell lymphoma/leukemia 11A isoform 2 |
| NCBI Synonym Full Names: | B-cell CLL/lymphoma 11A (zinc finger protein) |
| NCBI Official Symbol: | BCL11A |
| NCBI Official Synonym Symbols: | EVI9; CTIP1; ZNF856; HBFQTL5; BCL11A-L; BCL11A-S; BCL11a-M; BCL11A-XL |
| NCBI Protein Information: | B-cell lymphoma/leukemia 11A; EVI-9; BCL-11A; zinc finger protein 856; C2H2-type zinc finger protein; COUP-TF-interacting protein 1; ecotropic viral integration site 9 homolog; ecotropic viral integration site 9 protein homolog; B-cell CLL/lymphoma 11A (z |
| UniProt Protein Name: | B-cell lymphoma/leukemia 11A |
| UniProt Synonym Protein Names: | B-cell CLL/lymphoma 11A; COUP-TF-interacting protein 1; Ecotropic viral integration site 9 protein homolog; EVI-9; Zinc finger protein 856 |
| Protein Family: | B-cell lymphoma/leukemia |
| UniProt Gene Name: | BCL11A |
| UniProt Entry Name: | BC11A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using BCL11A antibody (CAB5445) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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