Signal Transduction Antibodies 3

Anti-BBS10 Antibody (CAB8820)

(No reviews yet) Write a Review
SKU:
CAB8820
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-BBS10 Antibody
Antibody SKU:CAB8820
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 474-723 of human BBS10 (NP_078961.3).
Application:WB
Recommended Dilution:WB 1:200 - 1:3000
Reactivity:Human, Mouse
Positive Samples:A-549, A-431, HT-1080, HeLa, HepG2, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 474-723 of human BBS10 (NP_078961.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AENK DALE KTQT YLKV HSNL VIPD VELE TYIP YSTP TLTP TDTF QTVE TLTC LSLE RNRL TDYY EPLL KNNS TAYS TRGN RIEI SYEN LQVT NITR KGSM LPVS CKLP NMGT SQSY LSSS MPAG CVLP VGGN FEIL LHYY LLNY AKKC HQSE ETMV SMII ANAL LGIP KVLY KSKT GKYS FPHT YIRA VHAL QTNQ PLVS SQTG LESV MGKY QLLT SVLQ CLTK ILTI DMVI TVKR HPQK VHNQ DSED EL
Gene ID:79738
Uniprot:Q8TAM1
Cellular Location:Cell projection, cilium
Calculated MW:80kDa
Observed MW:80kDa
Synonyms:BBS10, C12orf58
Background:This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes. Mutations in this gene cause Bardet-Biedl syndrome type 10.
UniProt Protein Function:BBS10: Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation. Defects in BBS10 are the cause of Bardet-Biedl syndrome type 10 (BBS10). Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, autosomal recessive disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Belongs to the TCP-1 chaperonin family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 12q21.2

Molecular Function:protein binding

Biological Process: chaperone-mediated protein complex assembly; photoreceptor cell maintenance; regulation of protein complex assembly; retinal homeostasis; sensory cilium biogenesis

Disease: Bardet-biedl Syndrome 10

NCBI Summary:This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes. Mutations in this gene cause Bardet-Biedl syndrome type 10. [provided by RefSeq, Jan 2010]
UniProt Code:Q8TAM1
NCBI GenInfo Identifier:97043964
NCBI Gene ID:79738
NCBI Accession:Q8TAM1.2
UniProt Secondary Accession:Q8TAM1,Q96CW2, Q9H5D2,
UniProt Related Accession:Q8TAM1
Molecular Weight:80,838 Da
NCBI Full Name:Bardet-Biedl syndrome 10 protein
NCBI Synonym Full Names:Bardet-Biedl syndrome 10
NCBI Official Symbol:BBS10  
NCBI Official Synonym Symbols:C12orf58  
NCBI Protein Information:Bardet-Biedl syndrome 10 protein
UniProt Protein Name:Bardet-Biedl syndrome 10 protein
Protein Family:Bardet-Biedl syndrome 10 protein
UniProt Gene Name:BBS10  
UniProt Entry Name:BBS10_HUMAN
Anti-BBS10 Polyclonal Antibody (CAB8820)Western blot analysis of extracts of various cell lines, using BBS10 antibody (CAB8820) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s.
View AllClose

0 Reviews

View AllClose

Related Products