Anti-BAP31 Antibody (CAB2259)
- SKU:
- CAB2259
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- 6C6-AG
- Synonyms:
- BAP31
- Synonyms:
- CDM
- Synonyms:
- DDCH
- Synonyms:
- DXS1357E
- Research Area:
- Cell Death
Description
| Product Name: | BAP31 Rabbit mAb |
| Product Code: | CAB2259 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | 6C6-AG, BAP31, CDM, DDCH, DXS1357E |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human BAP31 |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, 293T, U-251MG, Mouse lung, Mouse liver, Mouse kidney, Rat lung |
| Immunogen: | A synthesized peptide derived from human BAP31 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10134 |
| Uniprot: | P51572 |
| Cellular Location: | Endoplasmic reticulum membrane, Endoplasmic reticulum-Golgi intermediate compartment membrane, Multi-pass membrane protein |
| Calculated MW: | 25kDa |
| Observed MW: | 28kDa |
| UniProt Protein Function: | BCAP31 iso2: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis. Homodimer and heterodimer with BCAP29. Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II. Interacts with PTPLB. Ubiquitous. Belongs to the BCAP29/BCAP31 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: Xq28 Cellular Component: endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; membrane; clathrin-coated vesicle; endoplasmic reticulum; integral to plasma membrane; lipid particle; cytosol Molecular Function:protein binding; MHC class I protein binding; protein complex binding Biological Process: intracellular protein transport; ER to Golgi vesicle-mediated transport; antigen processing and presentation of peptide antigen via MHC class I; elevation of cytosolic calcium ion concentration; apoptosis; reduction of endoplasmic reticulum calcium ion concentration; positive regulation of caspase activity; spermatogenesis; cell structure disassembly during apoptosis; elevation of mitochondrial calcium ion concentration Disease: Deafness, Dystonia, And Cerebral Hypomyelination |
| NCBI Summary: | This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis. Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS), a neonatal disorder. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 16. [provided by RefSeq, Jan 2012] |
| UniProt Code: | P51572 |
| NCBI GenInfo Identifier: | 1705725 |
| NCBI Gene ID: | 10134 |
| NCBI Accession: | P51572.3 |
| UniProt Secondary Accession: | P51572,Q13836, Q96CF0, B3KQ79, D3DWV5, |
| UniProt Related Accession: | P51572 |
| Molecular Weight: | 34,752 Da |
| NCBI Full Name: | B-cell receptor-associated protein 31 |
| NCBI Synonym Full Names: | B-cell receptor-associated protein 31 |
| NCBI Official Symbol: | BCAP31 |
| NCBI Official Synonym Symbols: | CDM; DDCH; BAP31; 6C6-AG; DXS1357E |
| NCBI Protein Information: | B-cell receptor-associated protein 31; p28 Bap31; BCR-associated protein Bap31; 6C6-AG tumor-associated antigen |
| UniProt Protein Name: | B-cell receptor-associated protein 31 |
| UniProt Synonym Protein Names: | 6C6-AG tumor-associated antigen; Protein CDM; p28 |
| Protein Family: | B-cell receptor-associated protein |
| UniProt Gene Name: | BCAP31 |
| UniProt Entry Name: | BAP31_HUMAN |
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