Name: Anti-BAIAP2L1 Antibody (CAB8238)
Brand: Signal Transduction Antibodies 3
SKU: CAB8238
Availability: OutOfStock

Antibody Name:	BAIAP2L1 Rabbit Polyclonal Antibody
Antibody SKU:	CAB8238
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 198-388 of human BAIAP2L1 (NP_061330.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	HepG2, HeLa, 293T, A-549, Mouse lung

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 198-388 of human BAIAP2L1 (NP_061330.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	DKHC GFAN HIHY YHLQ SAEL LNSK LPRW QETC VDAI KVPE KIMN MIEE IKTP ASTP VSGT PQAS PMIE RSNV VRKD YDTL SKCS PKMP PAPS GRAY TSPL IDMF NNPA TAAP NSQR VNNS TGTS EDPS LQRS VSVA TGLN MMKK QKVK TIFP HTAG SNKT LLSF AQGD VITL LIPE EKDG WLYG EHDV SKA
Gene ID:	55971
Uniprot:	Q9UHR4
Cellular Location:	Cytoplasm, cytoskeleton
Calculated MW:	56kDa
Observed MW:	57kDa

Synonyms:

BAIAP2L1, IRTKS

Background:

This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation.

UniProt Protein Function:	IRTKS: May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.
UniProt Protein Details:	Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol; actin cytoskeleton Molecular Function:protein binding; actin binding Biological Process: regulation of insulin receptor signaling pathway; response to bacterium; positive regulation of actin filament polymerization; plasma membrane organization and biogenesis
NCBI Summary:	This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009]
UniProt Code:	Q9UHR4
NCBI GenInfo Identifier:	32171238
NCBI Gene ID:	55971
NCBI Accession:	NP_061330.2
UniProt Secondary Accession:	Q9UHR4,Q75L21, Q75L22, Q96CV4, Q9H5F5, Q9Y2M8, A4D268
UniProt Related Accession:	Q9UHR4
Molecular Weight:	57kd
NCBI Full Name:	brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
NCBI Synonym Full Names:	BAI1-associated protein 2-like 1
NCBI Official Symbol:	BAIAP2L1
NCBI Official Synonym Symbols:	IRTKS
NCBI Protein Information:	brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
UniProt Protein Name:	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
UniProt Synonym Protein Names:	Insulin receptor tyrosine kinase substrate
UniProt Gene Name:	BAIAP2L1
UniProt Entry Name:	BI2L1_HUMAN

Anti-BAIAP2L1 Polyclonal Antibody (CAB8238)

Western blot analysis of extracts of various cell lines, using BAIAP2L1 antibody (CAB8238) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.

Antibodies

Anti-BAIAP2L1 Antibody (CAB15173)

BAIAP2L1 Antibody (PACO00985)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)