Cell Biology Antibodies 11
Anti-BAG2 Antibody (CAB7763)
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- SKU:
- CAB7763
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-BAG2 Antibody |
| Antibody SKU: | CAB7763 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-211 of human BAG2 (NP_004273.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | HeLa, Jurkat, HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-211 of human BAG2 (NP_004273.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAQA KINA KANE GRFC RSSS MADR SSRL LESL DQLE LRVE ALRE AATA VEQE KEIL LEMI HSIQ NSQD MRQI SDGE REEL NLTA NRLM GRTL TVEV SVET IRNP QQQE SLKH ATRI IDEV VNKF LDDL GNAK SHLM SLYS ACSS EVPH GPVD QKFQ SIVI GCAL EDQK KIKR RLET LLRN IENS DKAI KLLE HSKG AGSK TLQQ NAES RFN |
| Gene ID: | 9532 |
| Uniprot: | O95816 |
| Cellular Location: | |
| Calculated MW: | 20kDa/23kDa |
| Observed MW: | 24kDa |
| Synonyms: | BAG2, BAG-2, dJ417I1.2 |
| Background: | BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. |
| UniProt Protein Function: | BAG2: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. |
| UniProt Protein Details: | Protein type:Apoptosis Chromosomal Location of Human Ortholog: 6p12.1-p11.2 Cellular Component: cytosol Molecular Function:adenyl-nucleotide exchange factor activity; identical protein binding; protein binding Biological Process: protein folding; protein metabolic process |
| NCBI Summary: | BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95816 |
| NCBI GenInfo Identifier: | 12229698 |
| NCBI Gene ID: | 9532 |
| NCBI Accession: | O95816.1 |
| UniProt Secondary Accession: | O95816,Q08AS9, Q6FID0, B4DXE2, |
| UniProt Related Accession: | O95816 |
| Molecular Weight: | 20,189 Da |
| NCBI Full Name: | BAG family molecular chaperone regulator 2 |
| NCBI Synonym Full Names: | BCL2 associated athanogene 2 |
| NCBI Official Symbol: | BAG2 |
| NCBI Official Synonym Symbols: | BAG-2; dJ417I1.2 |
| NCBI Protein Information: | BAG family molecular chaperone regulator 2 |
| UniProt Protein Name: | BAG family molecular chaperone regulator 2 |
| UniProt Synonym Protein Names: | Bcl-2-associated athanogene 2 |
| Protein Family: | BAG family molecular chaperone regulator |
| UniProt Gene Name: | BAG2 |
| UniProt Entry Name: | BAG2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using BAG2 antibody (CAB7763) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded human kidney using BAG2 antibody (CAB7763) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using BAG2 antibody (CAB7763) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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