Cell Biology Antibodies 16
Anti-B9D2 Antibody (CAB10627)
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- SKU:
- CAB10627
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-B9D2 Antibody |
| Antibody SKU: | CAB10627 |
| Antibody Size: | 20uL, 50 uL |
| Application: | IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-175 of human B9D2 (NP_085055.2). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-175 of human B9D2 (NP_085055.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAEV HVIG QIIG ASGF SESS LFCK WGIH TGAA WKLL SGVR EGQT QVDT PQIG DMAY WSHP IDLH FATK GLQG WPRL HFQV WSQD SFGR CQLA GYGF CHVP SSPG THQL ACPT WRPL GSWR EQLA RAFV GGGP QLLH GDTI YSGA DRYR LHTA AGGT VHLE IGLL LRNF DRYG VEC |
| Gene ID: | 80776 |
| Uniprot: | Q9BPU9 |
| Cellular Location: | Cytoplasm, Nucleus, cilium axoneme, cilium basal body, cytoskeleton |
| Calculated MW: | 19kDa |
| Observed MW: | Refer to figures |
| Synonyms: | B9D2, ICIS-1, MKS10, MKSR2 |
| Background: | This gene encodes a B9 domain protein, which are exclusively found in ciliated organisms. The gene is upregulated during mucociliary differentiation, and the encoded protein localizes to basal bodies and cilia. Disrupting expression of this gene results in ciliogenesis defects. |
| UniProt Protein Function: | B9D2: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Defects in B9D2 are the cause of Meckel syndrome type 10 (MKS10). MKS10 is a disorder characterized by a combination of renal cysts and variably associated features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia and cysts, and polydactyly. Belongs to the B9D family. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: centrosome; cytosol Molecular Function:gamma-tubulin binding; protein binding Biological Process: sister chromatid cohesion Disease: Meckel Syndrome, Type 10 |
| NCBI Summary: | This gene encodes a B9 domain protein, which are exclusively found in ciliated organisms. The gene is upregulated during mucociliary differentiation, and the encoded protein localizes to basal bodies and cilia. Disrupting expression of this gene results in ciliogenesis defects. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q9BPU9 |
| NCBI GenInfo Identifier: | 226371646 |
| NCBI Gene ID: | 80776 |
| NCBI Accession: | NP_085055 |
| UniProt Related Accession: | Q9BPU9 |
| Molecular Weight: | 19kDa |
| NCBI Full Name: | B9 domain-containing protein 2 |
| NCBI Synonym Full Names: | B9 domain containing 2 |
| NCBI Official Symbol: | B9D2 |
| NCBI Official Synonym Symbols: | MKS10; MKSR2; ICIS-1; JBTS34 |
| NCBI Protein Information: | B9 domain-containing protein 2 |
| UniProt Protein Name: | B9 domain-containing protein 2 |
| UniProt Synonym Protein Names: | MKS1-related protein 2 |
| Protein Family: | B9 domain-containing protein |
| UniProt Gene Name: | B9D2 |
| UniProt Entry Name: | B9D2_HUMAN |
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