Cell Biology Antibodies 16
Anti-AZI2 Antibody (CAB17756)
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- SKU:
- CAB17756
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-AZI2 Antibody |
| Antibody SKU: | CAB17756 |
| Antibody Size: | 20uL, 50 uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of Human AZI2. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | A synthetic peptide of Human AZI2. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 64343 |
| Uniprot: | Q9H6S1 |
| Cellular Location: | |
| Calculated MW: | 26kDa/28kDa/44kDa |
| Observed MW: | Refer to figures |
| Synonyms: | AZ2, NAP1, TILP, AZI2 |
| Background: | AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008] |
| UniProt Protein Function: | AZI2: Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFN-beta promoter activation via TICAM1. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 3p24.1 Cellular Component: cytoplasm Molecular Function:protein binding Biological Process: tumor necrosis factor production; I-kappaB kinase/NF-kappaB cascade; T cell activation; interleukin-6 production; interferon-gamma production; mitotic cell cycle; interferon-alpha production |
| NCBI Summary: | AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9H6S1 |
| NCBI GenInfo Identifier: | 11968003 |
| NCBI Gene ID: | 64343 |
| NCBI Accession: | NP_071906.1 |
| UniProt Secondary Accession: | Q9H6S1,Q86W99, Q9BQF1, A8K3M2, |
| UniProt Related Accession: | Q9H6S1 |
| Molecular Weight: | 44,935 Da |
| NCBI Full Name: | 5-azacytidine-induced protein 2 isoform a |
| NCBI Synonym Full Names: | 5-azacytidine induced 2 |
| NCBI Official Symbol: | AZI2 |
| NCBI Official Synonym Symbols: | AZ2; NAP1; TILP |
| NCBI Protein Information: | 5-azacytidine-induced protein 2; NAK-associated protein 1; 5-azacytidine induced gene 2; NF-kappa-B-activating kinase-associated protein 1 |
| UniProt Protein Name: | 5-azacytidine-induced protein 2 |
| UniProt Synonym Protein Names: | NF-kappa-B-activating kinase-associated protein 1; Nak-associated protein 1; TILP |
| Protein Family: | 5-azacytidine-induced protein |
| UniProt Gene Name: | AZI2 |
| UniProt Entry Name: | AZI2_HUMAN |
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