Cell Biology Antibodies 9

Anti-ATXN10 Antibody (CAB4586)

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SKU:
CAB4586
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ATXN10
Synonyms:
E46L
Synonyms:
HUMEEP
Synonyms:
SCA10
Synonyms:
ataxin-10
Research Area:
Cell Biology

Description

Product Name:ATXN10 Rabbit pAb
Product Code:CAB4586
Size:20uL, 50uL, 100uL
Synonyms:ATXN10, E46L, HUMEEP, SCA10, ataxin-10
Applications:WB, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 346-475 of human ATXN10 (NP_037368.1).
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, SKOV3, LO2, HL-60, 293T, Mouse heart, Mouse kidney, Mouse liver, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 346-475 of human ATXN10 (NP_037368.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ETTN IFSN CGCV RAEG DISN VANG FKSH LIRL IGNL CYKN KDNQ DKVN ELDG IPLI LDNC NISD SNPF LTQW VIYA IRNL TEDN SQNQ DLIA KMEE QGLA DASL LKKV GFEV EKKG EKLI LKST RDTP KP
Gene ID:25814
Uniprot:Q9UBB4
Cellular Location:Cytoplasm, perinuclear region
Calculated MW:46kDa/53kDa
Observed MW:45kDa
UniProt Protein Function:ataxin-10: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. Defects in ATXN10 are the cause of spinocerebellar ataxia type 10 (SCA10). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA10 is an autosomal dominant cerebellar ataxia (ADCA). Defects in ATXN1 may be a cause of nephronophthisis a chronic tubulo-interstitial nephropathy taht leads to anemia, polyuria, polydipsia, isosthenuria and death in uremia. Belongs to the ataxin-10 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell development/differentiation

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: extracellular space; cell soma; membrane; perinuclear region of cytoplasm; cytoplasm; dendrite; plasma membrane; cytosol

Molecular Function:identical protein binding; protein binding

Biological Process: nervous system development; neurite development

Disease: Spinocerebellar Ataxia 10

NCBI Summary:This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jul 2016]
UniProt Code:Q9UBB4
NCBI GenInfo Identifier:17372671
NCBI Gene ID:25814
NCBI Accession:Q9UBB4.1
UniProt Related Accession:Q9UBB4
Molecular Weight:
NCBI Full Name:Ataxin-10
NCBI Synonym Full Names:ataxin 10
NCBI Official Symbol:ATXN10  
NCBI Official Synonym Symbols:E46L; SCA10; HUMEEP  
NCBI Protein Information:ataxin-10
UniProt Protein Name:Ataxin-10
UniProt Synonym Protein Names:Brain protein E46 homolog; Spinocerebellar ataxia type 10 protein
UniProt Gene Name:ATXN10  
UniProt Entry Name:ATX10_HUMAN
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