Cell Biology Antibodies 9
Anti-ATXN10 Antibody (CAB4586)
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- SKU:
- CAB4586
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ATXN10
- Synonyms:
- E46L
- Synonyms:
- HUMEEP
- Synonyms:
- SCA10
- Synonyms:
- ataxin-10
- Research Area:
- Cell Biology
Description
| Product Name: | ATXN10 Rabbit pAb |
| Product Code: | CAB4586 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ATXN10, E46L, HUMEEP, SCA10, ataxin-10 |
| Applications: | WB, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 346-475 of human ATXN10 (NP_037368.1). |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, SKOV3, LO2, HL-60, 293T, Mouse heart, Mouse kidney, Mouse liver, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 346-475 of human ATXN10 (NP_037368.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ETTN IFSN CGCV RAEG DISN VANG FKSH LIRL IGNL CYKN KDNQ DKVN ELDG IPLI LDNC NISD SNPF LTQW VIYA IRNL TEDN SQNQ DLIA KMEE QGLA DASL LKKV GFEV EKKG EKLI LKST RDTP KP |
| Gene ID: | 25814 |
| Uniprot: | Q9UBB4 |
| Cellular Location: | Cytoplasm, perinuclear region |
| Calculated MW: | 46kDa/53kDa |
| Observed MW: | 45kDa |
| UniProt Protein Function: | ataxin-10: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. Defects in ATXN10 are the cause of spinocerebellar ataxia type 10 (SCA10). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA10 is an autosomal dominant cerebellar ataxia (ADCA). Defects in ATXN1 may be a cause of nephronophthisis a chronic tubulo-interstitial nephropathy taht leads to anemia, polyuria, polydipsia, isosthenuria and death in uremia. Belongs to the ataxin-10 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell development/differentiation Chromosomal Location of Human Ortholog: 22q13.31 Cellular Component: extracellular space; cell soma; membrane; perinuclear region of cytoplasm; cytoplasm; dendrite; plasma membrane; cytosol Molecular Function:identical protein binding; protein binding Biological Process: nervous system development; neurite development Disease: Spinocerebellar Ataxia 10 |
| NCBI Summary: | This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jul 2016] |
| UniProt Code: | Q9UBB4 |
| NCBI GenInfo Identifier: | 17372671 |
| NCBI Gene ID: | 25814 |
| NCBI Accession: | Q9UBB4.1 |
| UniProt Related Accession: | Q9UBB4 |
| Molecular Weight: | |
| NCBI Full Name: | Ataxin-10 |
| NCBI Synonym Full Names: | ataxin 10 |
| NCBI Official Symbol: | ATXN10 |
| NCBI Official Synonym Symbols: | E46L; SCA10; HUMEEP |
| NCBI Protein Information: | ataxin-10 |
| UniProt Protein Name: | Ataxin-10 |
| UniProt Synonym Protein Names: | Brain protein E46 homolog; Spinocerebellar ataxia type 10 protein |
| UniProt Gene Name: | ATXN10 |
| UniProt Entry Name: | ATX10_HUMAN |
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