Epigenetics & Nuclear Signaling Antibodies 3

Anti-ATRIP Antibody (CAB5041)

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SKU:
CAB5041
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ATRIP
Research Area:
Epigenetics and Nuclear Signaling

Description

Product Name:ATRIP Rabbit pAb
Product Code:CAB5041
Size:20uL, 50uL, 100uL
Synonyms:ATRIP
Applications:WB, IF, IP
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ATRIP (NP_569055.1).
Applications:WB, IF, IP
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200 IP 1:20 - 1:50
Reactivity:Human
Positive Samples:Jurkat, HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ATRIP (NP_569055.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAGT SAPG SKRR SEPP APRP GPPP GTGH PPSK RARG FSAA AAPD PDDP FGAH GDFT ADDL EELD TLAS QALS QCPA AARD VSSD HKVH RLLD GMSK NPSG KNRE TVPI KDNF ELEV LQAQ YKEL KEKM KVME EEVL IKNG EIKI LRDS LHQT ESVL EEQR RSHF LLEQ EKTQ ALSD KEKE FSKK LQSL QSEL QFKD AEMN ELRT KLQT SERA NKLA APSV SHVS PRKN PSVV IKPE ACSP QFGK TSFP TKES FSAN MSLP
Gene ID:84126
Uniprot:Q8WXE1
Cellular Location:Nucleus
Calculated MW:72kDa/76kDa/83kDa/85kDa
Observed MW:100kDa/113kDa
UniProt Protein Function:ATRIP: is required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. Heterodimerizes with ATR. The heterodimer binds replication protein A (RPA), a protein complex that subsequently is recruited to single stranded DNA (ssDNA). Its EEXXXDDL motif is required for the interaction with catalytic subunit of DNA-PK and its recruitment to sites of DNA damage. e for this protein is either identical to or adjacent to that of ATRIP. Some of the mRNAs that encode ATRIP also encode TREX1 in another reading frame. Three alternatively spliced human isoforms have been reported.
UniProt Protein Details:

Protein type:DNA-binding; DNA repair, damage; Cell cycle regulation

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: nucleoplasm; nucleus

Molecular Function:protein binding

Biological Process: DNA damage checkpoint; DNA repair; DNA replication

NCBI Summary:This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
UniProt Code:Q8WXE1
NCBI GenInfo Identifier:48428109
NCBI Gene ID:84126
NCBI Accession:Q8WXE1.1
UniProt Secondary Accession:Q8WXE1,Q69YK9, Q8NHQ2, Q8WUG7, Q96CL3, Q9HA30, A8K6A3 A8K714, B2RCE7, B4DU92, B5MEB7,
UniProt Related Accession:Q8WXE1
Molecular Weight:791
NCBI Full Name:ATR-interacting protein
NCBI Synonym Full Names:ATR interacting protein
NCBI Official Symbol:ATRIP  
NCBI Protein Information:ATR-interacting protein; ATM and Rad3-related-interacting protein
UniProt Protein Name:ATR-interacting protein
UniProt Synonym Protein Names:ATM and Rad3-related-interacting protein
Protein Family:ATR-interacting protein
UniProt Gene Name:ATRIP  
UniProt Entry Name:ATRIP_HUMAN
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