KO Validated Antibodies 2
Anti-ATPIF1 Antibody (CAB19946)[KO Validated]
- SKU:
- CAB19946
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-ATPIF1 Antibody [KO Validated] |
Antibody SKU: | CAB19946 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC IF |
Reactivity: | Human, Mouse |
Host Species: | Rabbit |
Immunogen: | Recombinant protein of human ATPIF1. |
Application: | WB IHC IF |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
Reactivity: | Human, Mouse |
Positive Samples: | 293T |
Immunogen: | Recombinant protein of human ATPIF1. |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 93974 |
Uniprot: | Q9UII2 |
Cellular Location: | Mitochondrion |
Calculated MW: | 6kDa/7kDa/12kDa |
Observed MW: | 12KDa |
Synonyms: | ATPIF1, ATPI, ATPIP, IP |
Background: | This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. |
UniProt Protein Function: | ATPIF1: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Homodimer at a pH value below 6.5, inactive homotetramer above. Belongs to the ATPase inhibitor family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Mitochondrial; Inhibitor Chromosomal Location of Human Ortholog: 1p35.3 Cellular Component: cell surface; mitochondrial proton-transporting ATP synthase complex; mitochondrion Molecular Function:5-formyltetrahydrofolate cyclo-ligase activity; angiostatin binding; ATPase binding; ATPase inhibitor activity; calmodulin binding; enzyme inhibitor activity; protein homodimerization activity Biological Process: angiogenesis; erythrocyte differentiation; folic acid and derivative biosynthetic process; generation of precursor metabolites and energy; heme biosynthetic process; mitochondrial depolarization; negative regulation of ATPase activity; negative regulation of endothelial cell proliferation; negative regulation of hydrolase activity; protein homooligomerization; protein homotetramerization |
NCBI Summary: | This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UII2 |
NCBI GenInfo Identifier: | 12585262 |
NCBI Gene ID: | 93974 |
NCBI Accession: | Q9UII2.1 |
UniProt Secondary Accession: | Q9UII2,Q5JXL8, Q6IAQ7, Q9BSL9, |
UniProt Related Accession: | Q9UII2 |
Molecular Weight: | |
NCBI Full Name: | ATPase inhibitor, mitochondrial |
NCBI Synonym Full Names: | ATPase inhibitory factor 1 |
NCBI Official Symbol: | ATPIF1 |
NCBI Official Synonym Symbols: | IP; ATPI; ATPIP |
NCBI Protein Information: | ATPase inhibitor, mitochondrial |
UniProt Protein Name: | ATPase inhibitor, mitochondrial |
UniProt Synonym Protein Names: | Inhibitor of F(1)F(o)-ATPase; IF(1); IF1 |
Protein Family: | ATPase inhibitor |
UniProt Gene Name: | ATPIF1 |
UniProt Entry Name: | ATIF1_HUMAN |