Cell Biology Antibodies 12

Anti-ATP7A Antibody (CAB8399)

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SKU:
CAB8399
Product Type:
Antibody
Applications:
WB
Applications:
IHC
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ATP7A Antibody
Antibody SKU:CAB8399
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human ATP7A (NP_000043.4).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human, Rat
Positive Samples:293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human ATP7A (NP_000043.4).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDPS MGVN SVTI SVEG MTCN SCVW TIEQ QIGK VNGV HHIK VSLE EKNA TIIY DPKL QTPK TLQE AIDD MGFD AVIH NPDP LPVL TDTL FLTV TASL TLPW DHIQ STLL KTKG VTDI KIYP QKRT VAVT IIPS IVNA NQIK ELVP ELSL DTGT LEKK SGAC EDHS MAQA GE
Gene ID:538
Uniprot:Q04656
Cellular Location:Cell membrane, Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Multi-pass membrane protein, Multi-pass membrane protein, cytosol, trans-Golgi network membrane
Calculated MW:11kDa/54kDa/154kDa/163kDa/165kDa/172kDa
Observed MW:163kDa
Synonyms:ATP7A, DSMAX, MK, MNK, SMAX3
Background:This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome. Alternatively-spliced transcript variants have been observed.
UniProt Protein Function:May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.
NCBI Summary:This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome. Alternatively-spliced transcript variants have been observed. [provided by RefSeq, Aug 2013]
UniProt Code:Q04656
NCBI GenInfo Identifier:223590241
NCBI Gene ID:538
NCBI Accession:Q04656.3
UniProt Secondary Accession:Q04656,O00227, O00745, Q9BYY8, B1AT72,
UniProt Related Accession:Q04656
Molecular Weight:11,522 Da
NCBI Full Name:Copper-transporting ATPase 1
NCBI Synonym Full Names:ATPase copper transporting alpha
NCBI Official Symbol:ATP7A  
NCBI Official Synonym Symbols:MK; MNK; DSMAX; SMAX3  
NCBI Protein Information:copper-transporting ATPase 1
UniProt Protein Name:Copper-transporting ATPase 1
UniProt Synonym Protein Names:Copper pump 1; Menkes disease-associated protein
UniProt Gene Name:ATP7A  
UniProt Entry Name:ATP7A_HUMAN
Anti-ATP7A Polyclonal Antibody (CAB8399)Western blot analysis of extracts of 293T cells, using ATP7A antibody (CAB8399) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-ATP7A Polyclonal Antibody (CAB8399)Immunohistochemistry of paraffin-embedded rat kidney using ATP7A antibody (CAB8399) at dilution of 1:100 (40x lens).
Anti-ATP7A Polyclonal Antibody (CAB8399)Immunohistochemistry of paraffin-embedded human liver damage using ATP7A antibody (CAB8399) at dilution of 1:100 (40x lens).
Anti-ATP7A Polyclonal Antibody (CAB8399)Immunohistochemistry of paraffin-embedded human stomach using ATP7A antibody (CAB8399) at dilution of 1:100 (40x lens).
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