Signal Transduction Antibodies 3
Anti-ATP6V1B2 Antibody (CAB16771)
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- SKU:
- CAB16771
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-ATP6V1B2 Antibody |
| Antibody SKU: | CAB16771 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 262-511 of human ATP6V1B2 (NP_001684.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse kidney, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 262-511 of human ATP6V1B2 (NP_001684.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NLAN DPTI ERII TPRL ALTT AEFL AYQC EKHV LVIL TDMS SYAE ALRE VSAA REEV PGRR GFPG YMYT DLAT IYER AGRV EGRN GSIT QIPI LTMP NDDI THPI PDLT GYIT EGQI YVDR QLHN RQIY PPIN VLPS LSRL MKSA IGEG MTRK DHAD VSNQ LYAC YAIG KDVQ AMKA VVGE EALT SDDL LYLE FLQK FERN FIAQ GPYE NRTV FETL DIGW QLLR IFPK EMLK RIPQ STLS EFYP RDSA KH |
| Gene ID: | 526 |
| Uniprot: | P21281 |
| Cellular Location: | Endomembrane system, Melanosome, Peripheral membrane protein |
| Calculated MW: | 56kDa |
| Observed MW: | 57kDa |
 | Western blot - ATP6V1B2 Rabbit pAb (CAB16771) |
| Synonyms: | ATP6V1B2, ATP6B1B2, ATP6B2, DOOD, HO57, VATB, VPP3, Vma2, ZLS2 |
| Background: | This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. |
| UniProt Protein Function: | ATP6V1B2: Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the ATPase alpha/beta chains family. |
| UniProt Protein Details: | Protein type:EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase Chromosomal Location of Human Ortholog: 8p21.3 Cellular Component: ruffle; microvillus; intracellular membrane-bound organelle; lysosomal membrane; integral to membrane; melanosome; plasma membrane; endomembrane system; cytosol Molecular Function:hydrogen ion transmembrane transporter activity; hydrogen ion transporting ATPase activity, rotational mechanism; ATP binding Biological Process: ATP metabolic process; interaction with host; proton transport; cellular iron ion homeostasis; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; transmembrane transport Disease: Zimmermann-laband Syndrome 2 |
| NCBI Summary: | This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P21281 |
| NCBI GenInfo Identifier: | 12643271 |
| NCBI Gene ID: | 526 |
| NCBI Accession: | P21281.3 |
| UniProt Related Accession: | P21281 |
| Molecular Weight: | |
| NCBI Full Name: | V-type proton ATPase subunit B, brain isoform |
| NCBI Synonym Full Names: | ATPase H+ transporting V1 subunit B2 |
| NCBI Official Symbol: | ATP6V1B2 |
| NCBI Official Synonym Symbols: | DOOD; HO57; VATB; VPP3; Vma2; ZLS2; ATP6B2; ATP6B1B2 |
| NCBI Protein Information: | V-type proton ATPase subunit B, brain isoform |
| UniProt Protein Name: | V-type proton ATPase subunit B, brain isoform |
| UniProt Synonym Protein Names: | Endomembrane proton pump 58 kDa subunit; HO57; Vacuolar proton pump subunit B 2 |
| UniProt Gene Name: | ATP6V1B2 |
| UniProt Entry Name: | VATB2_HUMAN |
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