Signal Transduction Antibodies 2

Anti-ATP6V0A1 Antibody (CAB15258)

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SKU:
CAB15258
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-ATP6V0A1 Antibody
Antibody SKU:CAB15258
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 60-300 of human ATP6V0A1 (NP_001123493.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 60-300 of human ATP6V0A1 (NP_001123493.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EMDR KLRF VEKE IRKA NIPI MDTG ENPE VPFP RDMI DLEA NFEK IENE LKEI NTNQ EALK RNFL ELTE LKFI LRKT QQFF DEMA DPDL LEES SSLL EPSE MGRG TPLR LGFV AGVI NRER IPTF ERML WRVC RGNV FLRQ AEIE NPLE DPVT GDYV HKSV FIIF FQGD QLKN RVKK ICEG FRAS LYPC PETP QERK EMAS GVNT RIDD LQMV LNQT EDHR QRVL QAAA KNIR VWFI KVRK M
Gene ID:535
Uniprot:Q93050
Cellular Location:Cytoplasmic vesicle membrane, Melanosome, Multi-pass membrane protein
Calculated MW:95kDa/96kDa
Observed MW:Refer to figures
Synonyms:ATP6V0A1, ATP6N1, ATP6N1A, Stv1, VPP1, Vph1, a1
Background:This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:ATP6V0A1: Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle. Belongs to the V-ATPase 116 kDa subunit family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Transporter, iron

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: nucleoplasm; Golgi apparatus; phagocytic vesicle membrane; intracellular membrane-bound organelle; cytoplasm; melanosome; integral to membrane; plasma membrane; endosome membrane; vacuolar proton-transporting V-type ATPase complex

Molecular Function:protein binding; hydrogen ion transporting ATPase activity, rotational mechanism; ATPase binding

Biological Process: interaction with host; vacuolar acidification; ATP synthesis coupled proton transport; cellular iron ion homeostasis; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; transmembrane transport

NCBI Summary:This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q93050
NCBI GenInfo Identifier:59803038
NCBI Gene ID:535
NCBI Accession:Q93050.3
UniProt Secondary Accession:Q93050,Q8N5G7, Q9NSX0, B7Z3B7,
UniProt Related Accession:Q93050
Molecular Weight:96,600 Da
NCBI Full Name:V-type proton ATPase 116 kDa subunit a isoform 1
NCBI Synonym Full Names:ATPase, H+ transporting, lysosomal V0 subunit a1
NCBI Official Symbol:ATP6V0A1  
NCBI Official Synonym Symbols:a1; Stv1; VPP1; Vph1; ATP6N1; ATP6N1A  
NCBI Protein Information:V-type proton ATPase 116 kDa subunit a isoform 1; V-ATPase 116 kDa; vacuolar proton pump subunit 1; vacuolar proton pump, subunit 1; vacuolar-type H(+)-ATPase 115 kDa subunit; vacuolar adenosine triphosphatase subunit Ac116; vacuolar proton translocating ATPase 116 kDa subunit A; H(+)-transporting two-sector ATPase, 116 kDa accessory protein A1; clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD); ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1A (110/116kD)
UniProt Protein Name:V-type proton ATPase 116 kDa subunit a isoform 1
UniProt Synonym Protein Names:Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; Vacuolar adenosine triphosphatase subunit Ac116; Vacuolar proton pump subunit 1; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1
Protein Family:V-type proton ATPase
UniProt Gene Name:ATP6V0A1  
UniProt Entry Name:VPP1_HUMAN
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