Signal Transduction Antibodies 2

Anti-ATP5H Antibody (CAB4425)

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SKU:
CAB4425
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ATP5H
Synonyms:
ATPQ

Description

Product Name:ATP5H Rabbit pAb
Product Code:CAB4425
Size:20uL, 50uL, 100uL
Synonyms:ATP5H, ATPQ
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-161 of human ATP5H (NP_006347.1).
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:COS-7, HepG2, U-251MG, BxPC-3, HeLa, Mouse kidney, Mouse thymus, Mouse brain, Rat spinal cord
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-161 of human ATP5H (NP_006347.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAGR KLAL KTID WVAF AEII PQNQ KAIA SSLK SWNE TLTS RLAA LPEN PPAI DWAY YKAN VAKA GLVD DFEK KFNA LKVP VPED KYTA QVDA EEKE DVKS CAEW VSLS KARI VEYE KEME KMKN LIPF DQMT IEDL NEAF PETK LDKK KYPY WPHQ PIEN L
Gene ID:10476
Uniprot:O75947
Cellular Location:Mitochondrion, Mitochondrion inner membrane
Calculated MW:15kDa/18kDa
Observed MW:18kDa
UniProt Protein Function:ATP5H: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Belongs to the ATPase d subunit family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Mitochondrial; Energy Metabolism - oxidative phosphorylation; EC 3.6.3.14

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: nucleoplasm; mitochondrion; cytoplasm; mitochondrial inner membrane; mitochondrial proton-transporting ATP synthase complex

Molecular Function:ATPase activity; transmembrane transporter activity; hydrogen ion transmembrane transporter activity

Biological Process: cellular metabolic process; mitochondrial ATP synthesis coupled proton transport

NCBI Summary:Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the d subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. In addition, three pseudogenes are located on chromosomes 9, 12 and 15. [provided by RefSeq, Jun 2010]
UniProt Code:O75947
NCBI GenInfo Identifier:6831494
NCBI Gene ID:10476
NCBI Accession:O75947.3
UniProt Secondary Accession:O75947,Q9H3J4, B2R5L6,
UniProt Related Accession:O75947
Molecular Weight:Observed MW 18kDaCalculated MW 15kDa/18kDa
NCBI Full Name:ATP synthase subunit d, mitochondrial
NCBI Synonym Full Names:ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
NCBI Official Symbol:ATP5H  
NCBI Official Synonym Symbols:ATPQ  
NCBI Protein Information:ATP synthase subunit d, mitochondrial; My032 protein; ATPase subunit d; ATP synthase D chain, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1F0, subunit d; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d
UniProt Protein Name:ATP synthase subunit d, mitochondrial
UniProt Gene Name:ATP5H  
UniProt Entry Name:ATP5H_HUMAN
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