Cell Biology Antibodies 10

Anti-ATOX1 Antibody (CAB6874)

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SKU:
CAB6874
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ATOX1 Antibody
Antibody SKU:CAB6874
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-68 of human ATOX1 (NP_004036.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human
Positive Samples:SW480, K-562
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-68 of human ATOX1 (NP_004036.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MPKH EFSV DMTC GGCA EAVS RVLN KLGG VKYD IDLP NKKV CIES EHSM DTLL ATLK KTGK TVSY LGLE
Gene ID:475
Uniprot:O00244
Cellular Location:
Calculated MW:7kDa
Observed MW:12kDa
Synonyms:ATOX1, ATX1, HAH1
Background:This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome.
UniProt Protein Function:ATOX1: Could bind and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense. Belongs to the ATX1 family.
UniProt Protein Details:

Protein type:Carrier

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: cytosol

Molecular Function:metallochaperone activity; copper ion transmembrane transporter activity; copper ion binding; copper chaperone activity; copper-dependent protein binding

Biological Process: response to reactive oxygen species; cellular copper ion homeostasis; response to oxidative stress; copper ion transport; intracellular copper ion transport

NCBI Summary:This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. [provided by RefSeq, Jul 2008]
UniProt Code:O00244
NCBI GenInfo Identifier:7531045
NCBI Gene ID:475
NCBI Accession:O00244.1
UniProt Secondary Accession:O00244,Q2M1R6, Q56AP3, A8KAJ8, D3DQI2,
UniProt Related Accession:O00244
Molecular Weight:68
NCBI Full Name:Copper transport protein ATOX1
NCBI Synonym Full Names:antioxidant 1 copper chaperone
NCBI Official Symbol:ATOX1  
NCBI Official Synonym Symbols:ATX1; HAH1  
NCBI Protein Information:copper transport protein ATOX1; metal transport protein ATX1; ATX1 antioxidant protein 1 homolog
UniProt Protein Name:Copper transport protein ATOX1
UniProt Synonym Protein Names:Metal transport protein ATX1
Protein Family:Copper transport protein
UniProt Gene Name:ATOX1  
UniProt Entry Name:ATOX1_HUMAN
Anti-ATOX1 Antibody (CAB6874)Western blot analysis of extracts of various cell lines, using ATOX1 Antibody (CAB6874) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
Anti-ATOX1 Antibody (CAB6874)Immunofluorescence analysis of MCF7 cells using ATOX1 antibody (CAB6874). Blue: DAPI for nuclear staining.
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