Developmental Biology

Anti-ATOH7 Antibody (CAB7273)

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SKU:
CAB7273
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-ATOH7 Antibody
Antibody SKU:CAB7273
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 47-152 of human ATOH7 (NP_660161.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 47-152 of human ATOH7 (NP_660161.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ARER RRMQ GLNT AFDR LRRV VPQW GQDK KLSK YETL QMAL SYIM ALTR ILAE AERF GSER DWVG LHCE HFGR DHYL PFPG AKLP GESE LYSQ RLFG FQPE PFQM AT
Gene ID:220202
Uniprot:Q8N100
Cellular Location:Nucleus
Calculated MW:16kDa
Observed MW:Refer to figures
Synonyms:ATOH7, Math5, NCRNA, PHPVAR, RNANC, bHLHa13
Background:This intronless gene encodes a member of the basic helix-loop-helix family of transcription factors, with similarity to Drosophila atonal gene that controls photoreceptor development. Studies in mice suggest that this gene plays a central role in retinal ganglion cell and optic nerve formation. Mutations in this gene are associated with nonsyndromic congenital retinal nonattachment.
UniProt Protein Function:ATOH7: Transcription factor involved in the differentiation of retinal ganglion cells. Defects in ATOH7 are the cause of retinal non-attachment congenital non-syndromic (RNANC). A condition characterized by separation of the inner layers of the retina (neural retina) from the pigment epithelium. Clinical findings include lack of perception of light, massive retrolental mass, shallow anterior chamber, and nystagmus in otherwise normal individuals. RNANC is caused by a 6.5 kb deletion that spans a remote cis regulatory element 20 kb upstream from ATOH7.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 10q21.3|10q21.3-q22.1

Cellular Component: nucleus

Molecular Function:protein dimerization activity; DNA binding

Biological Process: circadian rhythm; transcription, DNA-dependent; regulation of transcription, DNA-dependent; optic nerve development; entrainment of circadian clock; cell differentiation

Disease: Persistent Hyperplastic Primary Vitreous, Autosomal Recessive

NCBI Summary:This intronless gene encodes a member of the basic helix-loop-helix family of transcription factors, with similarity to Drosophila atonal gene that controls photoreceptor development. Studies in mice suggest that this gene plays a central role in retinal ganglion cell and optic nerve formation. Mutations in this gene are associated with nonsyndromic congenital retinal nonattachment. [provided by RefSeq, Dec 2011]
UniProt Code:Q8N100
NCBI GenInfo Identifier:74750873
NCBI Gene ID:220202
NCBI Accession:Q8N100.1
UniProt Related Accession:Q8N100
Molecular Weight:152
NCBI Full Name:Protein atonal homolog 7
NCBI Synonym Full Names:atonal homolog 7 (Drosophila)
NCBI Official Symbol:ATOH7  
NCBI Official Synonym Symbols:Math5; NCRNA; RNANC; PHPVAR; bHLHa13  
NCBI Protein Information:protein atonal homolog 7; helix-loop-helix protein hATH-5; class A basic helix-loop-helix protein 13
UniProt Protein Name:Protein atonal homolog 7
UniProt Synonym Protein Names:Class A basic helix-loop-helix protein 13; bHLHa13; Helix-loop-helix protein hATH-5; hATH5
Protein Family:Protein atonal
UniProt Gene Name:ATOH7  
UniProt Entry Name:ATOH7_HUMAN
Anti-ATOH7 Antibody (CAB7273)Immunofluorescence analysis of A-549 cells using ATOH7 antibody (CAB7273).
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