Cell Biology Antibodies 2

Anti-ATL3 Antibody (CAB12196)

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SKU:
CAB12196
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ATL3 Antibody
Antibody SKU:CAB12196
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 360-440 of human ATL3 (NP_056274.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, 293T, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 360-440 of human ATL3 (NP_056274.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KDIY YNNM EEVC GGEK PYLS PDIL EEKH CEFK QLAL DHFK KTKK MGGK DFSF RYQQ ELEE EIKE LYEN FCKH NGSK NVFS T
Gene ID:25923
Uniprot:Q6DD88
Cellular Location:Endoplasmic reticulum membrane, Multi-pass membrane protein
Calculated MW:60kDa
Observed MW:50-60kDa
Synonyms:ATL3, HSN1F
Background:This gene encodes a member of a family of dynamin-like, integral membrane GTPases. The encoded protein is required for the proper formation of the network of interconnected tubules of the endoplasmic reticulum. Mutations in this gene may be associated with hereditary sensory neuropathy type IF. Alternatively spliced transcript variants that encode distinct isoforms have been described.
UniProt Protein Function:ATL3: GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. Belongs to the GBP family. Atlastin subfamily.
UniProt Protein Details:

Protein type:Membrane protein, integral; EC 3.6.5.-; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane

Molecular Function:GTPase activity; identical protein binding; GTP binding

Biological Process: endoplasmic reticulum organization and biogenesis; ER to Golgi vesicle-mediated transport; metabolic process; Golgi organization and biogenesis; protein homooligomerization

Disease: Neuropathy, Hereditary Sensory, Type If

NCBI Summary:This gene encodes a member of a family of dynamin-like, integral membrane GTPases. The encoded protein is required for the proper formation of the network of interconnected tubules of the endoplasmic reticulum. Mutations in this gene may be associated with hereditary sensory neuropathy type IF. Alternatively spliced transcript variants that encode distinct isoforms have been described. [provided by RefSeq, Feb 2014]
UniProt Code:Q6DD88
NCBI GenInfo Identifier:74736374
NCBI Gene ID:25923
NCBI Accession:Q6DD88.1
UniProt Secondary Accession:Q6DD88,Q8N7W5, Q9H8Q5, Q9UFL1,
UniProt Related Accession:Q6DD88
Molecular Weight:541
NCBI Full Name:Atlastin-3
NCBI Synonym Full Names:atlastin GTPase 3
NCBI Official Symbol:ATL3  
NCBI Official Synonym Symbols:HSN1F  
NCBI Protein Information:atlastin-3
UniProt Protein Name:Atlastin-3
Protein Family:Atlastin
UniProt Gene Name:ATL3  
UniProt Entry Name:ATLA3_HUMAN
Anti-ATL3 Antibody (CAB12196)Western blot analysis of extracts of various cell lines, using ATL3 antibody (CAB12196) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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