Autophagy Antibodies

Anti-ATG9B Antibody (CAB7406)

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SKU:
CAB7406
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Autophagy

Description

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Antibody Name:Anti-ATG9B Antibody
Antibody SKU:CAB7406
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 715-924 of human ATG9B (NP_775952.4).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, HL-60, Mouse liver, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 715-924 of human ATG9B (NP_775952.4).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HPLW RPPG HSSK FLGH LWGR VQQD AAAW GATS ARGP STPG VLSN CTSP LPEA FLAN LFVH PLLP PRDL SPTA PCPA AATA SLLA SISR IAQD PSSV SPGG TGGQ KLAQ LPEL ASAE MSLH VIYL HQLH QQQQ QQEP WGEA AASI LSRP CSSP SQPP SPDE EKPS WSSD GSSP ASSP RQQW GTQK ARNL FPGG FQVT TDTQ KEPD RASC TD
Gene ID:285973
Uniprot:Q674R7
Cellular Location:Cytoplasmic vesicle, Multi-pass membrane protein, autophagosome membrane
Calculated MW:36kDa/44kDa/101kDa
Observed MW:101kDa
Synonyms:ATG9B, APG9L2, NOS3AS, SONE
Background:This gene functions in the regulation of autophagy, a lysosomal degradation pathway. This gene also functions as an antisense transcript in the posttranscriptional regulation of the endothelial nitric oxide synthase 3 gene, which has 3' overlap with this gene on the opposite strand. Mutations in this gene and disruption of the autophagy process have been associated with multiple cancers. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:ATG9B: Plays a role in autophagy. Belongs to the ATG9 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Vesicle; Autophagy

Chromosomal Location of Human Ortholog: 7q36.1

Cellular Component: integral to membrane; cytoplasmic vesicle

Biological Process: autophagic vacuole formation

NCBI Summary:This gene functions in the regulation of autophagy, a lysosomal degradation pathway. This gene also functions as an antisense transcript in the posttranscriptional regulation of the endothelial nitric oxide synthase 3 gene, which has 3' overlap with this gene on the opposite strand. Mutations in this gene and disruption of the autophagy process have been associated with multiple cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
UniProt Code:Q674R7
NCBI GenInfo Identifier:74708555
NCBI Gene ID:285973
NCBI Accession:Q674R7.1
UniProt Related Accession:Q674R7
Molecular Weight:~ 101kDa
NCBI Full Name:Autophagy-related protein 9B
NCBI Synonym Full Names:autophagy related 9B
NCBI Official Symbol:ATG9B  
NCBI Official Synonym Symbols:SONE; APG9L2; NOS3AS  
NCBI Protein Information:autophagy-related protein 9B
UniProt Protein Name:Autophagy-related protein 9B
UniProt Synonym Protein Names:APG9-like 2; Nitric oxide synthase 3-overlapping antisense gene protein; Protein sONE
Protein Family:Autophagy-related protein
UniProt Gene Name:ATG9B  
UniProt Entry Name:ATG9B_HUMAN
Anti-ATG9B Antibody (CAB7406)Western blot analysis of extracts of various cell lines, using ATG9B antibody (CAB7406) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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